{"id":"W2795132568","doi":"10.1101/291575","title":"A Patient-Derived Cellular Model for Huntington’s Disease Reveals Phenotypes at Clinically Relevant CAG Lengths","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Huntington Society of Canada; Krembil Foundation; McMaster University","keywords":"Huntingtin; Huntingtin Protein; Biology; Huntington's disease; Phenotype; Trinucleotide repeat expansion; Polyglutamine tract; Telomerase reverse transcriptase; Telomerase; Proteostasis; Cell biology; Cell; Cell culture; Senescence; Genetics; Disease; Allele; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622496,0.0002959213,0.000328346,0.0002686324,0.0002824891,0.0003262031,0.0002434811,0.0005117949,0.002160952],"category_scores_gemma":[0.000151691,0.0001235278,0.0002238701,0.0002534058,0.000272867,0.0001727598,0.0002389432,0.0006065701,0.0006380986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689284,"about_ca_system_score_gemma":0.0002121217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006844952,"about_ca_topic_score_gemma":0.001130683,"domain_scores_codex":[0.9998289,0.00003916517,0.00002627014,0.00004517355,0.00004209217,0.00001834698],"domain_scores_gemma":[0.9998771,0.00003432307,0.00001720128,0.00003209515,0.00001128309,0.00002800361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001889223,0.000167548,0.0004799537,0.0000343022,0.00001344847,0.0006425676,0.00008426812,0.0002218946,0.9964121,0.0005109584,0.0002225745,0.00102139],"study_design_scores_gemma":[0.0001092603,0.001703999,0.009844183,0.00001977217,0.00005442014,0.006169489,0.0001883055,0.003419894,0.9666033,0.0004065571,0.0114583,0.00002255853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904959,0.0004982419,0.004914608,0.0002114049,0.00006988055,0.00007512219,0.001876685,0.0001012758,0.001756897],"genre_scores_gemma":[0.990943,0.0004711793,0.004381194,0.00007017514,0.000008775295,0.00007317612,0.001664807,0.00002151922,0.002366233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160952,"threshold_uncertainty_score":0.007229149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077829297548664,"score_gpt":0.2554346538722883,"score_spread":0.2246563608968017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}