{"id":"W2795182293","doi":"10.1089/ten.tea.2017.0476","title":"Development of PEI- <i>RANK</i> siRNA Complex Loaded PLGA Nanocapsules for the Treatment of Osteoporosis","year":2018,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Orta Doğu Teknik Üniversitesi","keywords":"RANKL; Nanocapsules; Osteoclast; Polyethylenimine; Osteoporosis; PLGA; Small interfering RNA; Chemistry; Osteoprotegerin; Pharmacology; Gene silencing; Cell biology; RANK Ligand; Cancer research; Activator (genetics); Receptor; Biochemistry; Materials science; Medicine; Internal medicine; Nanotechnology; Biology; RNA; Transfection; Nanoparticle; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000516228,0.00011118,0.0001433861,0.00001971803,0.00004036572,0.00000457224,0.0001206406,0.00005116134,0.00002655964],"category_scores_gemma":[0.00001166312,0.0000827663,0.0000585032,0.00003777765,0.00004476599,0.000001554825,0.00002074153,0.00001239973,0.000005906417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008759097,"about_ca_system_score_gemma":0.00002867675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009067739,"about_ca_topic_score_gemma":0.00001753322,"domain_scores_codex":[0.9994584,0.000004507338,0.0002047427,0.00013385,0.00006070228,0.0001378044],"domain_scores_gemma":[0.9996204,0.0000168664,0.00005590393,0.0002089561,0.00007164024,0.00002621533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004293507,0.00005353767,0.0000246825,0.00002645503,0.0001048947,1.477538e-7,0.0007037881,0.0002157593,0.9901373,0.00001306989,0.0007936886,0.007883768],"study_design_scores_gemma":[0.0002518843,0.0005414923,0.0002714457,0.00001459603,0.00001840285,0.000001109046,0.00005982145,0.0001784492,0.7281214,8.587396e-7,0.2704722,0.00006835537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888802,0.001113538,0.0094285,0.00003235958,0.0002009788,0.0002375557,0.00002980496,0.000008375267,0.00006873527],"genre_scores_gemma":[0.9925476,0.0001146056,0.006546872,0.00001341219,0.0002011137,0.00005906272,0.00005459283,0.00001381663,0.0004489189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2696785,"threshold_uncertainty_score":0.3375112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992185026796304,"score_gpt":0.2652062068463975,"score_spread":0.2352843565784344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}