{"id":"W2795182293","doi":"10.1089/ten.tea.2017.0476","title":"Development of PEI- <i>RANK</i> siRNA Complex Loaded PLGA Nanocapsules for the Treatment of Osteoporosis","year":2018,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Orta Doğu Teknik Üniversitesi","keywords":"RANKL; Nanocapsules; Osteoclast; Polyethylenimine; Osteoporosis; PLGA; Small interfering RNA; Chemistry; Osteoprotegerin; Pharmacology; Gene silencing; Cell biology; RANK Ligand; Cancer research; Activator (genetics); Receptor; Biochemistry; Materials science; Medicine; Internal medicine; Nanotechnology; Biology; RNA; Transfection; Nanoparticle; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580814,0.0002984509,0.0004302488,0.0002548302,0.0001297852,0.0002106198,0.0002939689,0.0004418094,0.0005008657],"category_scores_gemma":[0.0001597639,0.000221706,0.0002879844,0.0001016894,0.000197507,0.0002342593,0.000192796,0.0003683483,0.0002460489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554695,"about_ca_system_score_gemma":0.0003104447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007447706,"about_ca_topic_score_gemma":0.0008389573,"domain_scores_codex":[0.9998938,0.00001379668,0.00001357237,0.0000305381,0.00003273212,0.00001555375],"domain_scores_gemma":[0.9999276,0.00001507622,0.00002134632,0.000004627892,0.00001699957,0.00001427089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007923367,0.00003505834,0.00005079192,0.000119235,0.00001041391,0.00006995148,0.00001423959,0.000250742,0.9951806,0.00009465824,0.00005700715,0.004038051],"study_design_scores_gemma":[0.00004400067,0.000615774,0.0006974313,0.000009312876,0.00003936168,0.0002173639,0.000008349424,0.00221595,0.9932731,0.00002935793,0.002837158,0.00001270444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564465,0.007894228,0.03218779,0.000323711,0.0001618503,0.0002783581,0.0002503177,0.0004192345,0.002037805],"genre_scores_gemma":[0.9550427,0.003575216,0.03528845,0.0001775792,0.00004145618,0.0003427116,0.0002978441,0.00006237839,0.005171589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007447706,"threshold_uncertainty_score":0.001853526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992185026796304,"score_gpt":0.2652062068463975,"score_spread":0.2352843565784344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}