{"id":"W2795220663","doi":"10.1139/cjm-2018-0095","title":"The toxic effect of <i>Vu</i>-Defr, a defensin from <i>Vigna unguiculata</i> seeds, on <i>Leishmania amazonensis</i> is associated with reactive oxygen species production, mitochondrial dysfunction, and plasma membrane perturbation","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministerio de Ciencia, Tecnología e Innovación Productiva; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Vigna; Reactive oxygen species; Defensin; Nitric oxide; Biochemistry; Mitochondrion; Leishmania; Inner mitochondrial membrane; Antimicrobial; Microbiology; Botany; Parasite hosting","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008073634,0.0002010191,0.0001925915,0.0001071894,0.0001183571,0.0001675131,0.0001432743,0.0002300555,0.0007089363],"category_scores_gemma":[0.00008319863,0.00005979497,0.0002104285,0.00009644576,0.0001314075,0.0001301524,0.0001165686,0.0003279702,0.0001124877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001387032,"about_ca_system_score_gemma":0.0001239079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008810611,"about_ca_topic_score_gemma":0.001140354,"domain_scores_codex":[0.9999012,0.0000227764,0.00001042723,0.00001882629,0.00002508203,0.0000218201],"domain_scores_gemma":[0.9999329,0.00001731617,0.00002048335,0.000006861726,0.000009883326,0.00001252128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008958392,0.00001976574,0.0002345109,0.0000613043,0.000004504418,0.00005459313,0.00001191933,0.00001942277,0.9987589,0.00002052899,0.00001594993,0.0007090393],"study_design_scores_gemma":[0.00001105998,0.0008885925,0.01256272,0.000008444003,0.00002153494,0.0005114853,0.00005551236,0.0002772824,0.9838924,0.00003076805,0.001734112,0.000006030503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996055,0.001887728,0.0007267641,0.0000882003,0.00001962531,0.00001629939,0.0002024103,0.00001963572,0.0009843279],"genre_scores_gemma":[0.9969646,0.0006832369,0.001050726,0.00007360597,0.000006550269,0.00000815765,0.0004432248,0.000005651437,0.0007643303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008810611,"threshold_uncertainty_score":0.002371609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004003194368635017,"score_gpt":0.1686882183688024,"score_spread":0.1646850240001673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}