{"id":"W2795220663","doi":"10.1139/cjm-2018-0095","title":"The toxic effect of <i>Vu</i>-Defr, a defensin from <i>Vigna unguiculata</i> seeds, on <i>Leishmania amazonensis</i> is associated with reactive oxygen species production, mitochondrial dysfunction, and plasma membrane perturbation","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministerio de Ciencia, Tecnología e Innovación Productiva; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Vigna; Reactive oxygen species; Defensin; Nitric oxide; Biochemistry; Mitochondrion; Leishmania; Inner mitochondrial membrane; Antimicrobial; Microbiology; Botany; Parasite hosting","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507069,0.0001868991,0.0002676589,0.00006021556,0.0002160235,0.00002779917,0.0001322991,0.0002372097,0.00001276518],"category_scores_gemma":[0.0003972827,0.0001175665,0.00007002205,0.000116136,0.0004764707,0.000011128,0.00001594873,0.0001653383,0.000001711051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005291324,"about_ca_system_score_gemma":0.0001898805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866332,"about_ca_topic_score_gemma":0.003648602,"domain_scores_codex":[0.9989766,0.0001686614,0.000311665,0.0002606535,0.00006301761,0.0002193351],"domain_scores_gemma":[0.9987252,0.00007339419,0.0003869044,0.0001766995,0.0005048913,0.0001328806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000956075,0.000006640053,0.001080919,0.000004707744,0.000200731,0.000003376269,0.0001288037,0.000001990981,0.9903142,0.000007482655,0.007085845,0.0002092643],"study_design_scores_gemma":[0.0008875076,0.001531108,0.005472519,0.0000566426,0.00009079067,0.0002178549,0.00003894896,0.000002288866,0.971051,0.00003211665,0.02047807,0.0001411973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976188,0.0002810113,0.00001527498,0.0009443766,0.0007053703,0.0001741779,0.0001916183,0.000002880201,0.00006647827],"genre_scores_gemma":[0.9979225,0.00005386945,0.00004800623,0.0003985194,0.0008036414,0.000001860585,0.0004392493,0.00001591959,0.0003164466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01926321,"threshold_uncertainty_score":0.4794223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004003194368635017,"score_gpt":0.1686882183688024,"score_spread":0.1646850240001673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}