{"id":"W2795277537","doi":"10.1186/s13148-018-0464-5","title":"Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD","year":2018,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; BC Children's Hospital; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Rosetrees Trust","keywords":"DNA methylation; COPD; Epigenetics; CpG site; Parenchyma; Biology; Epigenomics; Methylation; Gene expression; Immunology; Differentially methylated regions; Pathology; DNA; Gene; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007784395,0.0003864238,0.0005331088,0.00008903194,0.0001379424,0.00006169183,0.0003214789,0.0006955898,0.00009692189],"category_scores_gemma":[0.0004828816,0.0003149877,0.0001171799,0.0002873733,0.0003588304,0.00001180337,0.0001660533,0.0003081257,0.00002672911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003146021,"about_ca_system_score_gemma":0.0002013056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000583192,"about_ca_topic_score_gemma":0.0004523202,"domain_scores_codex":[0.9965724,0.0004761682,0.001040667,0.0009717977,0.0004353338,0.0005036628],"domain_scores_gemma":[0.9978257,0.0002599345,0.0005530322,0.0007321943,0.0003787843,0.0002503753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008167343,0.000384865,0.1828824,0.000007537321,0.0002068372,0.000007853052,0.0002606958,0.0004361934,0.810303,0.000001823955,0.0002706556,0.004421435],"study_design_scores_gemma":[0.002503366,0.002947179,0.2133804,0.0001246277,0.000069473,8.179258e-7,0.00002543592,0.001061533,0.7780786,0.0001569951,0.001223988,0.0004275619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789242,0.000599895,0.01922878,0.0001264971,0.0002544951,0.0004393676,0.0002395233,0.00002760168,0.0001596153],"genre_scores_gemma":[0.9874794,0.0005032998,0.009944349,0.0003840202,0.0005829753,0.00002706083,0.0008018906,0.00007127588,0.0002057296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0322244,"threshold_uncertainty_score":0.9999302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03362453696346902,"score_gpt":0.3131380803171931,"score_spread":0.2795135433537241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}