{"id":"W2795292973","doi":"10.1038/nature25985","title":"Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Thermus thermophilus; Biology; Peptidoglycan; Transmembrane domain; Genetics; Cell biology; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725243,0.0002267634,0.0002768093,0.0003921014,0.0004990451,0.0006509003,0.0005756285,0.0003768013,0.0006370601],"category_scores_gemma":[0.0004047229,0.0002997435,0.0002397042,0.0004644275,0.0003603311,0.0003197674,0.000246825,0.00116576,0.0001734371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006988702,"about_ca_system_score_gemma":0.0004614541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00245395,"about_ca_topic_score_gemma":0.002024478,"domain_scores_codex":[0.9999391,0.000009033725,0.000002574366,0.00002132555,0.0000165132,0.00001135062],"domain_scores_gemma":[0.9998171,0.00005128654,0.00004541574,0.00002174299,0.00002022611,0.00004425167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003467201,0.00004471008,0.003212525,0.00007556742,0.00003269628,0.000305714,0.0001401794,0.007279146,0.9751846,0.004926327,0.0001612986,0.008290423],"study_design_scores_gemma":[0.0001305838,0.0007109657,0.04305201,0.00004656206,0.0001387707,0.0009923765,0.0005601796,0.2800594,0.6579518,0.006683454,0.009556625,0.0001173216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935388,0.0004331476,0.004696867,0.00009083826,0.00001298535,0.000006548624,0.00007190642,0.00005665922,0.001092091],"genre_scores_gemma":[0.9950451,0.0001805803,0.004233922,0.00001772232,0.000003851873,0.000005779154,0.0001582646,0.00002283595,0.0003320244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245395,"threshold_uncertainty_score":0.005070627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002488700241623939,"score_gpt":0.2176383147607563,"score_spread":0.2151496145191324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}