{"id":"W2795522351","doi":"10.21037/jovs.2018.03.08","title":"How can genetic diagnosis inform the decision of when to operate?","year":2018,"lang":"en","type":"review","venue":"Journal of Visualized Surgery","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Computer science; Genetic diagnosis; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345733,0.0008206094,0.001616805,0.00266326,0.0003576945,0.001495397,0.001287729,0.002446833,0.003957809],"category_scores_gemma":[0.005464276,0.0002996386,0.000695956,0.001424991,0.001324716,0.00259648,0.0007240995,0.003034642,0.002239847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00100012,"about_ca_system_score_gemma":0.00140241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00159271,"about_ca_topic_score_gemma":0.002063888,"domain_scores_codex":[0.9995408,0.0001325869,0.00008667487,0.00007997125,0.0001278051,0.00003212774],"domain_scores_gemma":[0.9975144,0.001774472,0.0001808982,0.00005270947,0.0003772601,0.000100263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006325597,0.00003386306,0.0005350363,0.008519911,0.0001342169,0.000517236,0.00008321678,0.0003325311,0.000331549,0.007210705,0.05940829,0.92283],"study_design_scores_gemma":[0.00002215901,0.00005428758,0.001310146,0.01664302,0.0002377012,0.006497481,0.0002137564,0.000198809,0.0002460448,0.01558782,0.9589382,0.00005053556],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007035259,0.9960054,0.000255672,0.00226591,0.0005827842,0.000002617308,0.00001986607,0.000007739674,0.0007897575],"genre_scores_gemma":[0.0009260589,0.9968952,0.0002877319,0.0006847819,0.0008538246,0.0000036678,0.00003338097,0.000002368311,0.0003130096],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003957809,"threshold_uncertainty_score":0.01324016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07766644624334021,"score_gpt":0.426475569787668,"score_spread":0.3488091235443278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}