{"id":"W2795556226","doi":"10.1128/jvi.00277-18","title":"Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Gp41; Biology; Glycoprotein; Epitope; Cytoplasm; Negative stain; Viral envelope; Virus; Molecular biology; Cleavage (geology); Biophysics; Virology; Membrane; Antibody; Cell biology; Electron microscope; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001859362,0.0002938456,0.0001640443,0.0001928289,0.000124281,0.0002689102,0.0002522776,0.0002019399,0.000594431],"category_scores_gemma":[0.0004155488,0.0001511582,0.0002731057,0.000138005,0.0001639969,0.0002659771,0.0001820147,0.0003514029,0.0001840582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939902,"about_ca_system_score_gemma":0.0001224853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004678054,"about_ca_topic_score_gemma":0.0003478749,"domain_scores_codex":[0.9998943,0.00001622412,0.0000075804,0.00001890446,0.0000425431,0.00002041567],"domain_scores_gemma":[0.9998254,0.00003841084,0.00004332484,0.00001770315,0.00004529444,0.00002994151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134188,0.00001032729,0.0004596668,0.00002139649,0.00001109576,0.00006096572,0.00003589346,0.0001042166,0.9986538,0.00005361136,0.00001028549,0.0004652926],"study_design_scores_gemma":[0.00002237085,0.0005310919,0.02683095,0.0000151158,0.00003942626,0.0007842012,0.0001911621,0.00377567,0.9666178,0.0001118914,0.001065439,0.00001500923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985061,0.0002034046,0.0009496884,0.000009833269,0.000002822533,0.000005925683,0.00008764181,0.000008097873,0.0002265702],"genre_scores_gemma":[0.995773,0.0002112793,0.002055283,0.00003658265,0.000003126012,0.00001736106,0.00109011,0.00001832281,0.0007949247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000594431,"threshold_uncertainty_score":0.002133012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483947783558837,"score_gpt":0.3324285499719572,"score_spread":0.3075890721363688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}