{"id":"W2795575061","doi":"10.1016/j.celrep.2018.03.039","title":"Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Rehabilitation Institute; Sinai Health System; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; SickKids Foundation; University of Toronto; University Health Network","funders":"National Human Genome Research Institute; National Institute of General Medical Sciences; Ontario Genomics Institute; Terry Fox Research Institute; Government of Canada; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Cdc25; PTEN; Triple-negative breast cancer; Cancer research; Kinome; Biology; Wee1; PI3K/AKT/mTOR pathway; Cell cycle; Cancer; Breast cancer; Cyclin-dependent kinase 1; Kinase; Cell biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002593187,0.000440554,0.0004069075,0.0005277973,0.0002436367,0.0005813637,0.0002409781,0.0001889116,0.001199295],"category_scores_gemma":[0.00009015488,0.0001271172,0.0002342939,0.0002732357,0.0002246225,0.0001852575,0.0002643848,0.000639747,0.0003095221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004916717,"about_ca_system_score_gemma":0.0005353303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508407,"about_ca_topic_score_gemma":0.002685236,"domain_scores_codex":[0.9998909,0.00001673431,0.000008669774,0.00001866901,0.00003224104,0.00003277576],"domain_scores_gemma":[0.999948,0.000006039729,0.00001009296,0.000006482879,0.00000864409,0.00002063365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003204058,0.0001578709,0.0009091931,0.0001605197,0.00001883532,0.0002732861,0.00003262618,0.000468461,0.972473,0.001259362,0.0003386607,0.02358789],"study_design_scores_gemma":[0.00006352744,0.0007358533,0.003149915,0.00001855404,0.00005373687,0.0006577785,0.00003929775,0.0008674172,0.9768222,0.0001687655,0.01741502,0.000007930505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955049,0.02515612,0.006913045,0.0007175829,0.0001278372,0.0002842016,0.0005599264,0.0002017647,0.01099053],"genre_scores_gemma":[0.985185,0.008433969,0.003445618,0.00008882122,0.0000220888,0.00006433515,0.0003833501,0.00001255356,0.002364238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199295,"threshold_uncertainty_score":0.004012048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459552932684959,"score_gpt":0.2967751558826908,"score_spread":0.2821796265558412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}