{"id":"W2795575996","doi":"10.1371/journal.pmed.1002548","title":"Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children","year":2018,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Medical Research Council; Centers for Disease Control and Prevention; University of Florida; National Institutes of Health; Diabetes UK; Zentrum für Regenerative Therapien Dresden; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; University of Colorado; National Center for Advancing Translational Sciences; Wellcome Trust; Deutsche Forschungsgemeinschaft; Juvenile Diabetes Research Foundation International","keywords":"Type 1 diabetes; Medicine; Autoantibody; Diabetes mellitus; Human leukocyte antigen; Type 2 diabetes; Genotype; Islet; Internal medicine; HLA-DQB1; HLA-DQ; Prospective cohort study; Immunology; Endocrinology; Antibody; Biology; Genetics; Antigen; Haplotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347665,0.0001167992,0.0002128129,0.0000668986,0.00004162288,0.000005351425,0.00008854793,0.00005023251,0.000007774723],"category_scores_gemma":[0.000585611,0.00009317088,0.00001273654,0.0001701276,0.0001256759,0.000002345727,0.0000753935,0.00005492835,0.000002112706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008643763,"about_ca_system_score_gemma":0.00003467571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001359345,"about_ca_topic_score_gemma":0.000445805,"domain_scores_codex":[0.9992027,0.00004827743,0.0001945998,0.0002578291,0.0001108843,0.0001856981],"domain_scores_gemma":[0.9996024,0.00002125212,0.0000775701,0.000141943,0.0001124257,0.00004437728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002586132,0.0001174553,0.9548747,0.00001110539,0.0001882213,2.842573e-7,0.0008819405,0.000003561754,0.04300591,0.000002412965,0.0001355568,0.0007529955],"study_design_scores_gemma":[0.001163823,0.002058105,0.9788064,0.00009504912,0.00005415023,1.775011e-7,0.0006049509,0.00005517763,0.01696367,0.00006038932,0.00002454557,0.000113602],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983726,0.0008184954,0.00001536747,0.00008679175,0.00003902359,0.0005453021,0.00001250567,0.000007283263,0.0001026498],"genre_scores_gemma":[0.9991503,0.0001579344,0.0003897724,0.0001159947,0.0001236372,0.00001881722,0.00001211701,0.00001274122,0.00001873652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02604225,"threshold_uncertainty_score":0.3799398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008710309273229234,"score_gpt":0.2521488575939918,"score_spread":0.2434385483207626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}