{"id":"W2795575996","doi":"10.1371/journal.pmed.1002548","title":"Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children","year":2018,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Medical Research Council; Centers for Disease Control and Prevention; University of Florida; National Institutes of Health; Diabetes UK; Zentrum für Regenerative Therapien Dresden; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; University of Colorado; National Center for Advancing Translational Sciences; Wellcome Trust; Deutsche Forschungsgemeinschaft; Juvenile Diabetes Research Foundation International","keywords":"Type 1 diabetes; Medicine; Autoantibody; Diabetes mellitus; Human leukocyte antigen; Type 2 diabetes; Genotype; Islet; Internal medicine; HLA-DQB1; HLA-DQ; Prospective cohort study; Immunology; Endocrinology; Antibody; Biology; Genetics; Antigen; Haplotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001934336,0.0009074943,0.0005794764,0.001063835,0.0008685171,0.0008303267,0.0005876113,0.0009083149,0.001339925],"category_scores_gemma":[0.003938279,0.0009268753,0.001422341,0.001500001,0.0006673771,0.0007584105,0.0007813277,0.001654182,0.0003370367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006421155,"about_ca_system_score_gemma":0.0006612042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01021491,"about_ca_topic_score_gemma":0.00822399,"domain_scores_codex":[0.998774,0.0004383738,0.00009604399,0.000272372,0.0002285619,0.0001905336],"domain_scores_gemma":[0.9975429,0.0005662491,0.0009105647,0.0002164423,0.000230215,0.0005336847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001219402,0.00004696077,0.9992583,0.000004300271,0.00006595409,0.00006408396,0.00005294024,0.00002584324,0.00004862639,0.000008530101,0.00004337536,0.0002591345],"study_design_scores_gemma":[0.00003473661,0.0003971664,0.9984535,0.00001384573,0.00007380227,0.0004704399,0.0001928098,0.0001658144,0.00004580495,0.00002345779,0.0001211805,0.000007383349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992377,0.0001858495,0.00009976111,0.00003303725,0.000007262694,0.00001545656,0.0002659386,0.000003010744,0.0001519938],"genre_scores_gemma":[0.9988996,0.0001807904,0.0002714806,0.00004276922,0.00001147315,0.00003100939,0.0004107145,0.000005062859,0.0001471243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021491,"threshold_uncertainty_score":0.02031088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008710309273229234,"score_gpt":0.2521488575939918,"score_spread":0.2434385483207626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}