{"id":"W2795608361","doi":"","title":"MethylSight: Taking a wider view of lysine methylation through computer-aided discovery to provide insight into the human methyl-lysine proteome","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Carleton University","funders":"","keywords":"Lysine; Methylation; Human proteome project; Proteome; Biology; Computational biology; Protein methylation; Histone; Function (biology); DNA methylation; Biochemistry; Cell biology; Proteomics; Amino acid; Methyltransferase; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011841,0.0005258344,0.0005431465,0.0006993475,0.0002319718,0.0008878662,0.0005319443,0.0007326385,0.001768181],"category_scores_gemma":[0.0014188,0.0002355,0.0005609783,0.0006659841,0.0003054369,0.0009635712,0.000600847,0.0007727407,0.000442194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004531054,"about_ca_system_score_gemma":0.0006670821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311452,"about_ca_topic_score_gemma":0.002134342,"domain_scores_codex":[0.999785,0.00005652308,0.000009989589,0.00006940362,0.00006456253,0.00001443883],"domain_scores_gemma":[0.9996808,0.0001403734,0.0000504648,0.00006405373,0.00003581611,0.00002859968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002124609,0.0002466458,0.03830271,0.001184342,0.0008478332,0.0005819498,0.0003221217,0.1182642,0.4400379,0.0197077,0.009191002,0.369189],"study_design_scores_gemma":[0.0001241195,0.0004333235,0.01225854,0.00005466811,0.0001778393,0.0006122752,0.0000554981,0.8143337,0.1223058,0.02454254,0.02499551,0.0001062653],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3307787,0.005720033,0.6375575,0.002276655,0.0001732851,0.0001099973,0.007084887,0.009952842,0.006345975],"genre_scores_gemma":[0.5340437,0.002749422,0.4552235,0.000368631,0.00007226891,0.00008955018,0.005241083,0.0003058805,0.001906004],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001768181,"threshold_uncertainty_score":0.006262243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092297048098978,"score_gpt":0.2717301730370679,"score_spread":0.2508072025560781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}