{"id":"W2795675647","doi":"10.1101/296194","title":"Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in HLRCC","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; School of Medicine, New York University; National Institutes of Health; Canada Research Chairs; Princess Margaret Cancer Foundation; University of Toronto; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Cancer research; Protein tyrosine phosphatase; Chemistry; Phosphorylation; Phosphatase; Mutation; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954975,0.0002281079,0.0002075452,0.0004035602,0.0001894235,0.000187839,0.0001613025,0.0003942134,0.001258682],"category_scores_gemma":[0.0002531247,0.0001347516,0.0001958939,0.0001998181,0.0003520204,0.0001278578,0.0002108099,0.0003690559,0.0002020551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770989,"about_ca_system_score_gemma":0.00007450087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007961972,"about_ca_topic_score_gemma":0.0006936689,"domain_scores_codex":[0.9998716,0.00001628082,0.00001375091,0.00004031494,0.0000325488,0.00002552724],"domain_scores_gemma":[0.9998595,0.00002309882,0.00005857925,0.00001331041,0.00001679356,0.00002877431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004000663,0.00004359168,0.01567603,0.00006507411,0.00003332375,0.004350242,0.00007215499,0.0001769532,0.9759965,0.0001888346,0.0002089766,0.002788317],"study_design_scores_gemma":[0.00009630759,0.0005826671,0.3947538,0.0000231108,0.0001414031,0.03710012,0.0002396288,0.007288717,0.5556899,0.0005537916,0.003503155,0.00002725131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980621,0.0003893617,0.00091498,0.00006519253,0.00001052881,0.0000137695,0.0001015246,0.00003624613,0.0004063649],"genre_scores_gemma":[0.9994102,0.0000986775,0.0002213379,0.00002450893,0.000003772489,0.000005279794,0.00006009154,0.00000382597,0.0001723416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258682,"threshold_uncertainty_score":0.004210651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335223402092069,"score_gpt":0.2312140082215672,"score_spread":0.2178617742006465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}