{"id":"W2795719567","doi":"10.1016/j.cell.2018.10.037","title":"Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; National Institutes of Health; Janssen Biotech; Innovative Medicines Initiative; Genome Canada; Medical Research Council Canada; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; AbbVie; Merck KGaA; Novartis Pharma; Novartis; Boehringer Ingelheim Stiftung; Pfizer","keywords":"Tunicamycin; Glycosylation; Biology; Mycobacterium tuberculosis; Nucleoside; Antibiotics; Microbiology; Biochemistry; Tuberculosis; Endoplasmic reticulum; Unfolded protein response","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148877,0.0005418967,0.0003298334,0.0003706879,0.0003283015,0.0007483776,0.0005246188,0.0009168792,0.001806294],"category_scores_gemma":[0.0002570606,0.0003503173,0.0003066922,0.0004235009,0.0004136358,0.001098479,0.00037882,0.001378168,0.0009973524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008089719,"about_ca_system_score_gemma":0.0003909926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830465,"about_ca_topic_score_gemma":0.0008027041,"domain_scores_codex":[0.9999467,0.00001177425,0.000005401336,0.0000105982,0.00001256713,0.00001306214],"domain_scores_gemma":[0.9999263,0.000009613861,0.00002237294,0.000009624888,0.00001422247,0.00001786389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007809404,0.0001293146,0.003900084,0.001171608,0.00005077486,0.002440407,0.0004475316,0.01218793,0.820517,0.05584608,0.007720181,0.09480813],"study_design_scores_gemma":[0.0001880937,0.000890207,0.007636718,0.0003746784,0.0001926053,0.006961232,0.0005603607,0.04712448,0.5219823,0.06851721,0.3454364,0.0001358076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7210667,0.1430002,0.08119354,0.01617342,0.0009022625,0.0001962541,0.00165511,0.001201543,0.0346109],"genre_scores_gemma":[0.8988993,0.05262901,0.0388378,0.001140194,0.0002117955,0.00004944754,0.001310154,0.0001047745,0.006817672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806294,"threshold_uncertainty_score":0.006042659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252593218219744,"score_gpt":0.2610553865609078,"score_spread":0.2485294543787103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}