{"id":"W2795896160","doi":"10.1128/jvi.02261-17","title":"Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; International Centre for Genetic Engineering and Biotechnology; Canadian Institutes of Health Research; Bill and Melinda Gates Foundation; Office of Science; National Institutes of Health; Canada Research Chairs; University of Cape Town; Science and Technology Facilities Council; National Research Foundation; Poliomyelitis Research Foundation; Government of Canada; Argonne National Laboratory; U.S. Department of Energy","keywords":"Neutralization; Gp41; Epitope; Context (archaeology); Biology; Virology; Trimer; Antibody; Monoclonal antibody; V3 loop; Glycosylation; Virus; Viral entry; Glycan; Glycoprotein; Genetics; Viral replication; Chemistry; Dimer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008177041,0.0002805039,0.000193406,0.0001403395,0.0002007862,0.0003291963,0.0002708069,0.0004337469,0.00101437],"category_scores_gemma":[0.0001797357,0.0001206448,0.0003995453,0.0001334092,0.000226959,0.000117365,0.0001715055,0.0005815803,0.0003627821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240994,"about_ca_system_score_gemma":0.0001364199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001906628,"about_ca_topic_score_gemma":0.001361087,"domain_scores_codex":[0.9999074,0.00001080423,0.000009078191,0.00001873949,0.00002646692,0.00002754732],"domain_scores_gemma":[0.9998831,0.00002328355,0.00003654876,0.00001741727,0.0000114121,0.00002816617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001045138,0.00003671854,0.003248017,0.0000120753,0.000009177848,0.0005622891,0.00002870383,0.0002876095,0.9949924,0.0001431116,0.00004750853,0.0005278995],"study_design_scores_gemma":[0.000071121,0.001717474,0.1788678,0.00001965997,0.0001102268,0.009953336,0.0004577604,0.01001238,0.7953448,0.0005706947,0.002812315,0.00006236448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991618,0.00005289672,0.0002554022,0.00002238464,0.000005394894,0.000006684537,0.00009594375,0.000009782167,0.0003897424],"genre_scores_gemma":[0.9992754,0.00002933535,0.0002531222,0.00003468208,0.000002422469,0.000003519227,0.0001814785,0.000004742683,0.0002153231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906628,"threshold_uncertainty_score":0.003791094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009332875062811899,"score_gpt":0.2629180700870737,"score_spread":0.2535851950242619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}