{"id":"W2795906231","doi":"10.1253/circj.cj-17-0877","title":"Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages","year":2018,"lang":"en","type":"article","venue":"Circulation Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"University of South China; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"ABCA1; THP1 cell line; Apolipoprotein B; Signal transduction; Binding protein; ATP-binding cassette transporter; Chemistry; Plasma protein binding; Cell biology; Inflammation; ATP Binding Cassette Transporter 1; Transporter; Biochemistry; Biology; Cell culture; Cholesterol; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598334,0.0004394155,0.0005075359,0.0002373817,0.0003072532,0.0002972375,0.0002695025,0.0003268322,0.001408002],"category_scores_gemma":[0.000164402,0.000176114,0.0003861735,0.0002355244,0.0003532176,0.0001891522,0.0002002428,0.0008209649,0.0006886924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011637,"about_ca_system_score_gemma":0.0003422502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006805203,"about_ca_topic_score_gemma":0.0007906137,"domain_scores_codex":[0.9997293,0.00005452191,0.00002724374,0.00003847971,0.00007310924,0.00007728409],"domain_scores_gemma":[0.9998604,0.00003397917,0.00002485248,0.00002179845,0.00002752032,0.00003136828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000437792,0.0002054543,0.00009263343,0.000134747,0.00001369872,0.00004396751,0.0000254503,0.0000501768,0.9973666,0.00004139924,0.0001599402,0.001428234],"study_design_scores_gemma":[0.0001677445,0.001837114,0.005169022,0.00001882838,0.00005671664,0.0002175273,0.00006812426,0.001274157,0.9869991,0.00007190061,0.004108587,0.00001117549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885104,0.005120791,0.003309654,0.0003641499,0.0002065233,0.00007264778,0.0004219065,0.0001432136,0.00185069],"genre_scores_gemma":[0.9871411,0.003355105,0.005117502,0.000317012,0.00008174544,0.0001988932,0.000859638,0.00004156746,0.0028873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408002,"threshold_uncertainty_score":0.004710257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947339951524324,"score_gpt":0.260107919774607,"score_spread":0.2406345202593637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}