{"id":"W2795906231","doi":"10.1253/circj.cj-17-0877","title":"Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages","year":2018,"lang":"en","type":"article","venue":"Circulation Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"University of South China; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"ABCA1; THP1 cell line; Apolipoprotein B; Signal transduction; Binding protein; ATP-binding cassette transporter; Chemistry; Plasma protein binding; Cell biology; Inflammation; ATP Binding Cassette Transporter 1; Transporter; Biochemistry; Biology; Cell culture; Cholesterol; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001411352,0.0003588138,0.0005244514,0.0009955277,0.0004064297,0.0002133625,0.0002000086,0.0002385883,0.0003212283],"category_scores_gemma":[0.000366375,0.0003383432,0.0001647047,0.0008143103,0.00009963691,0.0004769286,0.00008136599,0.0008146936,0.0003584962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003663877,"about_ca_system_score_gemma":0.0002412257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004273931,"about_ca_topic_score_gemma":0.00001534873,"domain_scores_codex":[0.9967974,0.0002015031,0.0009996329,0.0004737725,0.0007794729,0.0007482516],"domain_scores_gemma":[0.9983413,0.00002917061,0.0003985448,0.0003345731,0.000277834,0.0006186363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135853,0.00007034639,0.01034328,0.0000765902,0.00003350776,0.00005860767,0.001784828,0.00004776072,0.975548,0.000114458,0.0002410292,0.01154571],"study_design_scores_gemma":[0.004962659,0.0003617659,0.0291137,0.002353729,0.0000676556,0.0007106255,0.0007111132,0.0003665613,0.953545,0.000438335,0.00666538,0.0007034364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952071,0.0002640038,0.001441026,0.0008178338,0.0004686942,0.001366785,0.00001564998,0.00009429853,0.000324623],"genre_scores_gemma":[0.995065,0.000008813628,0.001200812,0.000329939,0.002707393,0.00007772648,0.00002146858,0.00008044657,0.0005084262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02200299,"threshold_uncertainty_score":0.9999068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947339951524324,"score_gpt":0.260107919774607,"score_spread":0.2406345202593637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}