{"id":"W2795911726","doi":"10.1124/mol.118.111799","title":"Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Università degli Studi di Ferrara; University of Toronto; Cystic Fibrosis Canada","keywords":"Mutant; Cystic fibrosis transmembrane conductance regulator; Cyclic nucleotide-binding domain; Mutation; Allosteric regulation; Cystic fibrosis; Transmembrane domain; Mutant protein; Chemistry; Mutagenesis; Membrane protein; Cell biology; Biophysics; Biology; Biochemistry; Nucleotide; Membrane; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004245067,0.0004784217,0.0006383969,0.0002709505,0.0004506986,0.0006487602,0.0005826578,0.001031827,0.003594726],"category_scores_gemma":[0.0007764905,0.0001714582,0.0006207405,0.0001485252,0.0003296259,0.0004098737,0.0005053855,0.001078059,0.001903659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000630487,"about_ca_system_score_gemma":0.0003771107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236157,"about_ca_topic_score_gemma":0.0009406526,"domain_scores_codex":[0.9994686,0.0001141738,0.00004789295,0.00008399017,0.0001518335,0.0001335625],"domain_scores_gemma":[0.9995183,0.00007953076,0.0001489675,0.00005112322,0.00007653813,0.0001255927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00037703,0.00005317584,0.001017893,0.00003306196,0.00003197272,0.0004922894,0.00003305683,0.0001121833,0.9945345,0.0007517211,0.0004256484,0.002137387],"study_design_scores_gemma":[0.0001067726,0.0003272688,0.01318366,0.00002707468,0.00005621584,0.003783462,0.0001490988,0.004332437,0.968147,0.0004540121,0.009396711,0.00003637839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896055,0.0014294,0.004767169,0.001043765,0.0002616781,0.0000552613,0.0003755604,0.0001313446,0.002330357],"genre_scores_gemma":[0.9919341,0.0003890273,0.002983901,0.0003217337,0.00002503499,0.00002015897,0.0004308904,0.00004512113,0.003850045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003594726,"threshold_uncertainty_score":0.01202554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134691017420625,"score_gpt":0.3422488310428042,"score_spread":0.3287797293007417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}