{"id":"W2795911726","doi":"10.1124/mol.118.111799","title":"Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Università degli Studi di Ferrara; University of Toronto; Cystic Fibrosis Canada","keywords":"Mutant; Cystic fibrosis transmembrane conductance regulator; Cyclic nucleotide-binding domain; Mutation; Allosteric regulation; Cystic fibrosis; Transmembrane domain; Mutant protein; Chemistry; Mutagenesis; Membrane protein; Cell biology; Biophysics; Biology; Biochemistry; Nucleotide; Membrane; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002083161,0.0002060398,0.000404656,0.0001008649,0.0001268786,0.00001137854,0.0003423773,0.00008545566,0.00116974],"category_scores_gemma":[0.0004922376,0.0001449763,0.0001965207,0.0004888508,0.0007643541,0.00007876865,0.0002599653,0.0003463812,0.00008864235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251929,"about_ca_system_score_gemma":0.0001775749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009179499,"about_ca_topic_score_gemma":0.00001074941,"domain_scores_codex":[0.9980784,0.0002701904,0.0003712433,0.0003539782,0.0004274086,0.00049875],"domain_scores_gemma":[0.9987661,0.000321452,0.0001610746,0.0003892283,0.0002288841,0.000133298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008440834,0.0001312137,0.0005291444,0.0001284055,0.0002307061,0.0001330994,0.0004529016,0.00002975203,0.9942363,0.00008136645,0.002772424,0.0004305966],"study_design_scores_gemma":[0.001973723,0.0007371143,0.001916512,0.0001449094,0.0002971126,0.0002036212,0.00007473045,0.0008774809,0.9733868,0.0001201897,0.02013753,0.0001303156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902439,0.000501463,0.004015649,0.001612787,0.001298697,0.0007291292,0.00002617267,0.00005300788,0.001519227],"genre_scores_gemma":[0.9941402,0.00001715663,0.003457337,0.001838881,0.0002238459,0.00004788717,0.00001128236,0.00004070721,0.0002227118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02084954,"threshold_uncertainty_score":0.9997433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134691017420625,"score_gpt":0.3422488310428042,"score_spread":0.3287797293007417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}