{"id":"W2795969125","doi":"10.1002/slct.201800174","title":"2,4‐Disubstituted Phenylhydrazonopyrazolone and Isoxazolone Derivatives as Antibacterial Agents: Synthesis, Preliminary Biological Evaluation and Docking Studies","year":2018,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Memorial University of Newfoundland","funders":"Western Canada Research Grid; Western University; Compute Canada; Memorial University of Newfoundland; Wellcome Trust","keywords":"Antimicrobial; Chemistry; Docking (animal); Moiety; Antibacterial activity; Combinatorial chemistry; Stereochemistry; Pyrazolone; Bacteria; Organic chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002027614,0.0004610982,0.0003711625,0.0002419439,0.0001215651,0.0001937849,0.0003824091,0.0001724138,0.001829301],"category_scores_gemma":[0.0001355822,0.0001187302,0.0001738219,0.0002650713,0.0001654578,0.0001662967,0.0001316067,0.0002670855,0.0004183364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487506,"about_ca_system_score_gemma":0.0002986367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009864813,"about_ca_topic_score_gemma":0.00248926,"domain_scores_codex":[0.9999284,0.00002021655,0.000005609444,0.000008422082,0.00001885472,0.00001858806],"domain_scores_gemma":[0.9999334,0.000009280095,0.00001712207,0.000007848966,0.00001497241,0.00001734239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003075139,0.0002026301,0.0003269273,0.0004627558,0.00001873378,0.0002702572,0.00004913865,0.00233233,0.9825336,0.0003771042,0.0001906395,0.01292843],"study_design_scores_gemma":[0.0002807795,0.005291482,0.005074441,0.00004345032,0.0000769297,0.0005777645,0.00006677054,0.002990857,0.9750105,0.0001097791,0.01043701,0.00004023886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725147,0.01420915,0.007156854,0.0001662063,0.00006876845,0.0002752617,0.0007675148,0.0001458174,0.004695748],"genre_scores_gemma":[0.9808905,0.00739949,0.00825618,0.00005525159,0.00001442643,0.0001041787,0.0005396508,0.00001140439,0.002728929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829301,"threshold_uncertainty_score":0.006119609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07915913835060118,"score_gpt":0.3392216603040336,"score_spread":0.2600625219534324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}