{"id":"W2795969125","doi":"10.1002/slct.201800174","title":"2,4‐Disubstituted Phenylhydrazonopyrazolone and Isoxazolone Derivatives as Antibacterial Agents: Synthesis, Preliminary Biological Evaluation and Docking Studies","year":2018,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Memorial University of Newfoundland","funders":"Western Canada Research Grid; Western University; Compute Canada; Memorial University of Newfoundland; Wellcome Trust","keywords":"Antimicrobial; Chemistry; Docking (animal); Moiety; Antibacterial activity; Combinatorial chemistry; Stereochemistry; Pyrazolone; Bacteria; Organic chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004123359,0.0003372114,0.0004725574,0.00002543029,0.0003425042,0.00006904954,0.0001656802,0.0002926563,0.0009200669],"category_scores_gemma":[0.003374974,0.0002493737,0.00005704082,0.0001223053,0.0009334338,0.0001234464,0.0002294589,0.0001725426,0.00001011007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007763714,"about_ca_system_score_gemma":0.00004104337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000111657,"about_ca_topic_score_gemma":0.000002066496,"domain_scores_codex":[0.998322,0.00006770645,0.0003031537,0.0007208978,0.0002079802,0.0003783385],"domain_scores_gemma":[0.9986464,0.0006010136,0.0001927393,0.0002408297,0.0002022164,0.0001167691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003231335,0.0001317045,0.009009623,0.0001029842,0.0001848967,0.000005884865,0.0002106068,1.587898e-7,0.9681766,0.00001103151,0.00007626791,0.02176711],"study_design_scores_gemma":[0.0004616041,0.0001501998,0.01760942,0.0001545869,0.0001111657,0.00005053045,0.0003386009,0.0002122368,0.9795796,0.0004796767,0.0005045748,0.0003477523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952627,0.002037016,0.000007263783,0.0001615727,0.00006540796,0.0001259311,0.00001784867,0.0001175323,0.002204681],"genre_scores_gemma":[0.9981496,0.0009213734,0.0001951488,0.0000482867,0.0005216073,0.00008040298,0.0000332362,0.00001575196,0.00003457717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02141936,"threshold_uncertainty_score":0.9999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07915913835060118,"score_gpt":0.3392216603040336,"score_spread":0.2600625219534324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}