{"id":"W2796003820","doi":"10.1186/s13148-018-0463-6","title":"Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia","year":2018,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia; BC Children's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"Epigenetics; Biology; CpG site; DNA methylation; Epigenome; Gene; Methylation; Gene expression; Regulation of gene expression; Transcriptome; Genetics; Transcriptional regulation; Microarray; Gene cluster; Differentially methylated regions; Microarray analysis techniques; Promoter; Human genetics; Gene expression profiling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010831,0.0001183197,0.0001302921,0.0003144931,0.0001278789,0.0001999648,0.0001577532,0.0001238309,0.001351621],"category_scores_gemma":[0.0003496516,0.00007879414,0.0001039959,0.0002616464,0.0001493947,0.0000724183,0.0002489402,0.0001650025,0.0001463944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765328,"about_ca_system_score_gemma":0.0001164006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008640004,"about_ca_topic_score_gemma":0.001431247,"domain_scores_codex":[0.9998887,0.00001685433,0.00000765961,0.00003712474,0.00002825414,0.00002144187],"domain_scores_gemma":[0.9998806,0.00003018549,0.00003942179,0.00001854574,0.00001760506,0.00001359171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006966642,0.00003012333,0.2110986,0.0001031397,0.00006063333,0.0001922716,0.0003664093,0.0002541757,0.7685099,0.0002458527,0.0001619776,0.01828025],"study_design_scores_gemma":[0.000008807741,0.0001003986,0.933946,0.000008290916,0.00003603774,0.0007679269,0.00009643463,0.0005273658,0.06316327,0.0001771547,0.00116462,0.000003684774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968262,0.0006604987,0.00139783,0.00003720454,0.000002595236,0.000009937644,0.0004596722,0.00002251404,0.0005836468],"genre_scores_gemma":[0.9981335,0.0001564832,0.0006640564,0.00001645013,0.000003031181,0.00001131537,0.0004874307,0.000006010238,0.0005218246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351621,"threshold_uncertainty_score":0.004521608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0575544254731545,"score_gpt":0.3514449436248903,"score_spread":0.2938905181517358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}