{"id":"W2796092158","doi":"10.1016/j.molcel.2018.03.001","title":"Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Micropharma (Canada)","funders":"Argonne National Laboratory; Nuclear Physics; Direction Générale de l’Armement; Office of Science; Illinois State University; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; European Federation of Pharmaceutical Industries and Associations","keywords":"Biology; Binding site; Ribosomal protein; Computational biology; Ribosome; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001164646,0.0003440509,0.0002413514,0.00005573512,0.0001970866,0.0001161779,0.000361764,0.0002774738,0.0002850326],"category_scores_gemma":[0.00003609844,0.0003596683,0.0001579431,0.0001098779,0.0001592771,0.0000106943,0.0002933994,0.0000978953,0.0003787492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005910883,"about_ca_system_score_gemma":0.00007263972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005052321,"about_ca_topic_score_gemma":0.00003517135,"domain_scores_codex":[0.9980602,0.0000882562,0.0002725584,0.0007267685,0.0002568251,0.0005953666],"domain_scores_gemma":[0.9988741,0.000006745363,0.0001775897,0.0006471552,0.00004987579,0.0002445481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662574,0.00004721059,0.02470997,0.00002054976,0.00005772311,0.00005148084,0.00008060129,9.050515e-7,0.9249266,0.00000439999,0.0498591,0.00007521523],"study_design_scores_gemma":[0.0008600294,0.0002068068,0.002147321,0.00002812974,0.00004463915,0.00001638509,0.00001806104,0.000008211358,0.8704289,0.00000450281,0.125858,0.0003790728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938211,0.000317562,0.00147909,0.00009959284,0.0008285549,0.0002406815,0.00007448284,0.00003438289,0.003104536],"genre_scores_gemma":[0.9883443,0.0001073342,0.0008384084,0.000374569,0.0006393377,0.000001650621,0.0006176579,0.00008353256,0.008993286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07599887,"threshold_uncertainty_score":0.9998855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455220058229645,"score_gpt":0.2461030539595282,"score_spread":0.2315508533772317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}