{"id":"W2796142615","doi":"10.1002/acn3.560","title":"Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment","year":2018,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; National Cancer Institute; Servier; Eisai; Alzheimer's Foundation of America; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Alzheimer's Disease Research Foundation; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association","keywords":"Medicine; Single-nucleotide polymorphism; Methylation; SNP; DNA methylation; Oncology; Internal medicine; Alzheimer's disease; Apolipoprotein E; Whole blood; Dementia; Disease; Gene; Gene expression; Biology; Genetics; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988734,0.0003014257,0.0002714156,0.0006375256,0.0002180237,0.0002751626,0.0001343603,0.000260781,0.001064811],"category_scores_gemma":[0.0009136147,0.0001259291,0.0001160894,0.0004066747,0.0001217376,0.0001180911,0.0001653085,0.0002496892,0.0001627313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640295,"about_ca_system_score_gemma":0.00009175796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002167897,"about_ca_topic_score_gemma":0.002144733,"domain_scores_codex":[0.9999018,0.00002399594,0.000007556767,0.0000358066,0.00002000768,0.00001084638],"domain_scores_gemma":[0.9997094,0.00006481545,0.0001143369,0.00001683348,0.00003379327,0.00006075757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001528692,0.000049617,0.9815927,0.00003553967,0.0001231611,0.0001975472,0.00009296199,0.0000658378,0.01173757,0.00001701021,0.0001880872,0.004371302],"study_design_scores_gemma":[0.000008753199,0.00009262867,0.9989498,0.000002724539,0.00002211968,0.0002142625,0.00002563935,0.00007034309,0.0004908621,0.00002493768,0.00009607464,0.000001939124],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990115,0.0003900446,0.0000532868,0.00001795055,0.000004406982,0.000002514819,0.000318729,0.000005394761,0.0001960874],"genre_scores_gemma":[0.9991622,0.00009991267,0.000152801,0.00002514224,0.00001216317,0.000006129423,0.000258119,0.000001419663,0.0002821715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002167897,"threshold_uncertainty_score":0.004310548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2379250145553791,"score_gpt":0.4627299687156676,"score_spread":0.2248049541602885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}