{"id":"W2796176748","doi":"10.1016/j.str.2018.03.008","title":"A Pseudo-Kinase Double Act","year":2018,"lang":"en","type":"letter","venue":"Structure","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Innovative Medicines Initiative; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Genome Canada; AbbVie; Pfizer; Fundação de Amparo à Pesquisa do Estado de São Paulo; Boehringer Ingelheim","keywords":"Receptor tyrosine kinase; Protein kinase domain; Cyclin-dependent kinase 9; Proto-oncogene tyrosine-protein kinase Src; Kinase; Cell biology; Phosphorylation; Tyrosine kinase; PTK2; MAP kinase kinase kinase; Biochemistry; Chemistry; Biology; Mitogen-activated protein kinase kinase; Signal transduction; Protein kinase A; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.00006894334,0.000418643,0.0005597063,0.000301498,0.00009111476,0.0000661841,0.000376506,0.001487156,0.01494316],"category_scores_gemma":[0.00006781203,0.0003170323,0.000244427,0.0002887157,0.0002100816,0.00003238124,0.0001943117,0.003613039,0.0007820786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697202,"about_ca_system_score_gemma":0.0004119089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004959689,"about_ca_topic_score_gemma":0.00001004153,"domain_scores_codex":[0.9972589,0.00005663416,0.0002573114,0.0006888697,0.001066986,0.0006713021],"domain_scores_gemma":[0.9981999,0.00004489235,0.0001041162,0.001201683,0.0002614657,0.0001879265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001931478,0.000007641215,0.0001373135,0.0004765335,0.00009531866,0.003369625,0.00004931319,7.028146e-8,0.009402265,0.000004999163,0.9851362,0.0011276],"study_design_scores_gemma":[0.001440373,0.0002348573,0.0004355461,0.0001382187,0.0001124537,0.000493237,0.000005724148,0.000007548761,0.01223126,0.0002963497,0.9843131,0.0002912995],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05228233,0.0004657439,0.00001276358,0.90158,0.00137921,0.001646863,0.0002610915,0.0002461604,0.04212583],"genre_scores_gemma":[0.009001053,0.00003567204,0.001853831,0.8464694,0.023562,0.00002896821,0.002249921,0.0002662536,0.1165329],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07440704,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196729538195543,"score_gpt":0.3138734426914058,"score_spread":0.2919061473094504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}