{"id":"W2796208126","doi":"10.1016/j.cell.2018.03.039","title":"Pathogenic Germline Variants in 10,389 Adult Cancers","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":888,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute","keywords":"Biology; Germline; Genetics; Computational biology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931193,0.0003248462,0.0002714575,0.0009622644,0.0004323002,0.0004774236,0.0003175836,0.0005123509,0.003368475],"category_scores_gemma":[0.001144842,0.0001944857,0.0002485297,0.0009675274,0.0003279171,0.0001811692,0.0003656479,0.0002719056,0.0004525971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002152956,"about_ca_system_score_gemma":0.0002920191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003076336,"about_ca_topic_score_gemma":0.004611822,"domain_scores_codex":[0.9995709,0.00004016453,0.00004894994,0.0001545619,0.0001101906,0.00007515438],"domain_scores_gemma":[0.9996505,0.0001112168,0.0001078223,0.00003740461,0.00003554078,0.00005755693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008945127,0.0000558332,0.9379498,0.00009673709,0.0002082654,0.009251149,0.0004764478,0.0003235628,0.01906157,0.0008290875,0.001688546,0.02916444],"study_design_scores_gemma":[0.00009437035,0.0002320509,0.9495572,0.00008365311,0.000499306,0.02857345,0.0004799501,0.0005254242,0.006043606,0.001001706,0.01288917,0.00002009675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951136,0.001385825,0.0003521561,0.00005583507,0.00001637898,0.00000930414,0.001542541,0.00003078839,0.001493605],"genre_scores_gemma":[0.9975085,0.0005174704,0.0002875377,0.00003301413,0.00001433762,0.000005170099,0.0008550216,0.00001399675,0.0007648523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003368475,"threshold_uncertainty_score":0.01126862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006050756718381655,"score_gpt":0.2254527860441349,"score_spread":0.2194020293257532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}