{"id":"W2796219067","doi":"10.1371/journal.ppat.1007139","title":"RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Nursing Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Centers for Disease Control and Prevention; European Commission","keywords":"Tuberculosis; Mycobacterium tuberculosis; Secretion; Virulence; Epitope; Antigen; Immune system; Mycobacterium bovis; Tuberculosis vaccines; Biology; Microbiology; Virology; Vaccination; BCG vaccine; Antigenic variation; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007878533,0.0001580613,0.0005329349,0.0004333021,0.00002869182,0.000002807211,0.00005699332,0.0001828505,0.00004371678],"category_scores_gemma":[0.002080608,0.0001239201,0.00007871074,0.0004271596,0.0001203231,0.0000721713,0.00003173485,0.0003087865,0.000008634425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471261,"about_ca_system_score_gemma":0.0001407958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007972391,"about_ca_topic_score_gemma":0.0003126154,"domain_scores_codex":[0.9981024,0.0002285956,0.0006718006,0.0003799431,0.0002420424,0.0003752057],"domain_scores_gemma":[0.9990543,0.00008212669,0.0002042846,0.0003450697,0.000169524,0.0001447435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002706898,0.0005272864,0.1473788,0.0001373983,0.0000739544,0.00003030022,0.0007670046,0.0000213176,0.8460529,0.000006993568,0.0002292362,0.00206791],"study_design_scores_gemma":[0.002538892,0.003744218,0.9227293,0.0003565703,0.00002684012,0.00004477517,0.0004570076,0.002116187,0.06782999,0.00002756738,0.00002279981,0.0001058713],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976857,0.0001291372,0.000004662528,0.0008523911,0.0000497165,0.0007450153,0.0001534337,0.00002097488,0.0003589308],"genre_scores_gemma":[0.9991987,0.0003020766,0.0001110913,0.00002025854,0.0001613821,0.00002853154,0.00009259309,0.00001862753,0.00006679144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7782229,"threshold_uncertainty_score":0.5053315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08114599518979154,"score_gpt":0.3597690123207622,"score_spread":0.2786230171309707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}