{"id":"W2796219067","doi":"10.1371/journal.ppat.1007139","title":"RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Nursing Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Centers for Disease Control and Prevention; European Commission","keywords":"Tuberculosis; Mycobacterium tuberculosis; Secretion; Virulence; Epitope; Antigen; Immune system; Mycobacterium bovis; Tuberculosis vaccines; Biology; Microbiology; Virology; Vaccination; BCG vaccine; Antigenic variation; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439861,0.0003569463,0.0002453845,0.0001442389,0.00008574672,0.0002307418,0.0002601319,0.0003036353,0.001608198],"category_scores_gemma":[0.0001813987,0.0001443525,0.0002946421,0.0001330204,0.0001958885,0.0001428927,0.0002368007,0.0008682043,0.0005611404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958806,"about_ca_system_score_gemma":0.0001277209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005166397,"about_ca_topic_score_gemma":0.0004962071,"domain_scores_codex":[0.9997182,0.0000536746,0.00004496698,0.00005690824,0.00006920771,0.0000569601],"domain_scores_gemma":[0.9998147,0.0000357341,0.00005843613,0.0000352786,0.00001352688,0.00004246955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009183684,0.0000339343,0.0001371915,0.00001993354,0.000004084357,0.00003023785,0.000008575377,0.00002919706,0.9991459,0.00003002996,0.00001507453,0.0004540824],"study_design_scores_gemma":[0.00001611656,0.0004238524,0.00510303,0.000006315297,0.00001532223,0.000293096,0.0000238729,0.000717793,0.9919649,0.0000197624,0.001411516,0.00000431913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969927,0.0004076892,0.001420982,0.00005958051,0.00002611662,0.0000165895,0.0003493427,0.0000571128,0.0006698453],"genre_scores_gemma":[0.9944318,0.0001840334,0.001239439,0.00004621926,0.000006453643,0.0000215506,0.001479064,0.00005101556,0.002540591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608198,"threshold_uncertainty_score":0.005379915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08114599518979154,"score_gpt":0.3597690123207622,"score_spread":0.2786230171309707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}