{"id":"W2796322204","doi":"10.21037/apm.2018.03.09","title":"Efficacy of the combination neurokinin-1 receptor antagonist, palonosetron, and dexamethasone compared to others for the prophylaxis of chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials","year":2018,"lang":"en","type":"review","venue":"Annals of Palliative Medicine","topic":"Nausea and vomiting management","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre","funders":"","keywords":"Palonosetron; Medicine; Aprepitant; Granisetron; Randomized controlled trial; Meta-analysis; Dexamethasone; Vomiting; Nausea; NK1 receptor antagonist; Antagonist; Chemotherapy; Chemotherapy-induced nausea and vomiting; Anesthesia; Pharmacology; Internal medicine; Antiemetic; Receptor; Substance P; Neuropeptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009633502,0.002362231,0.02220052,0.00479625,0.0005764002,0.002804647,0.002337969,0.001859037,0.004111275],"category_scores_gemma":[0.02102397,0.001252048,0.02635882,0.005770116,0.0007733311,0.001789057,0.001152069,0.00167917,0.0002667498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002374501,"about_ca_system_score_gemma":0.003430849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003946593,"about_ca_topic_score_gemma":0.01022666,"domain_scores_codex":[0.9936388,0.002675295,0.002133965,0.0006885983,0.0006874924,0.0001758],"domain_scores_gemma":[0.9869802,0.009063462,0.002656562,0.0002527881,0.0008138653,0.0002331951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004633917,0.00004786377,0.001603144,0.5848515,0.3960066,0.00007767242,0.00007599466,0.0003293891,0.0002673535,0.00009115655,0.0003363096,0.011679],"study_design_scores_gemma":[0.001530858,0.0004849299,0.00198989,0.02683677,0.9675254,0.00006972625,0.00004614086,0.000134903,0.0001115755,0.0001118288,0.001137387,0.00002058168],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005152957,0.9934158,0.0002873008,0.000120258,0.000116923,0.0004050593,0.0003003628,0.00001734332,0.0001840187],"genre_scores_gemma":[0.1427128,0.8519835,0.001943543,0.0007839125,0.0002187341,0.001435482,0.0005896192,0.0000238595,0.0003085154],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02220052,"threshold_uncertainty_score":0.05094743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2974848731535085,"score_gpt":0.4643468646518481,"score_spread":0.1668619914983396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}