{"id":"W2796392037","doi":"10.1038/s41467-017-02107-w","title":"Parallel derivation of isogenic human primed and naive induced pluripotent stem cells","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Vlaamse regering; Centre Hospitalier Universitaire de Nantes; KU Leuven; University of Toronto; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Fonds Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Epiblast; Induced pluripotent stem cell; Reprogramming; Biology; Embryonic stem cell; Transcriptome; Regenerative medicine; Somatic cell; Stem cell; Computational biology; Genetics; Blastocyst; Cell biology; Embryo; Embryogenesis; Gene; Gene expression; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184562,0.000108668,0.0001198991,0.00007059149,0.0002251201,0.00001581186,0.0006979008,0.0003109964,0.000006772626],"category_scores_gemma":[0.00003343575,0.0001070087,0.00005025949,0.0001447654,0.0002681017,0.000005692881,0.0006210478,0.0003121344,0.000007967407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001871656,"about_ca_system_score_gemma":0.00006450997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000218127,"about_ca_topic_score_gemma":0.0001647951,"domain_scores_codex":[0.9990896,0.0001479629,0.0002191402,0.0002228486,0.0001578706,0.0001625979],"domain_scores_gemma":[0.9981198,0.00002880118,0.0001245504,0.001341879,0.0003193765,0.00006565095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002144002,0.00007573094,0.001170097,0.0000117335,0.00005149918,1.340867e-7,0.00008518209,0.000001146721,0.9963902,0.0006578379,0.0006647216,0.0008702704],"study_design_scores_gemma":[0.0004959626,0.0002634766,0.008238208,0.00001867824,0.00002066706,0.00000453576,0.000114177,0.0001183421,0.9720141,0.00008027743,0.01848662,0.00014492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941541,0.003257111,0.0001973796,0.0005899007,0.00005438066,0.0003587849,0.00001766758,0.00001262412,0.001358065],"genre_scores_gemma":[0.9961326,0.0006608242,0.002558853,0.0001156712,0.00005701904,0.0000280698,0.0001152724,0.000016394,0.0003152825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02437607,"threshold_uncertainty_score":0.4363688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117190061939964,"score_gpt":0.318938051397189,"score_spread":0.2877661507777894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}