{"id":"W2796392037","doi":"10.1038/s41467-017-02107-w","title":"Parallel derivation of isogenic human primed and naive induced pluripotent stem cells","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Vlaamse regering; Centre Hospitalier Universitaire de Nantes; KU Leuven; University of Toronto; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Fonds Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Epiblast; Induced pluripotent stem cell; Reprogramming; Biology; Embryonic stem cell; Transcriptome; Regenerative medicine; Somatic cell; Stem cell; Computational biology; Genetics; Blastocyst; Cell biology; Embryo; Embryogenesis; Gene; Gene expression; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005299041,0.0003165573,0.0002723906,0.0003086419,0.0001695929,0.000461557,0.0002717208,0.0002254475,0.001755098],"category_scores_gemma":[0.0003286015,0.0001551231,0.0002231107,0.0002332588,0.0001999822,0.0002176253,0.0005333376,0.000574594,0.0006306662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001082385,"about_ca_system_score_gemma":0.0003112924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233383,"about_ca_topic_score_gemma":0.0003195148,"domain_scores_codex":[0.9994783,0.00006889053,0.000107552,0.0001273497,0.0001791221,0.00003887414],"domain_scores_gemma":[0.9997854,0.00003774177,0.00003699713,0.00005999544,0.00004556766,0.0000344088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001617668,0.00005826526,0.0006921144,0.00007109309,0.00001052675,0.0001072483,0.00006256084,0.0001366675,0.9913781,0.0005534212,0.00009770902,0.006670507],"study_design_scores_gemma":[0.0000203999,0.000392636,0.004161601,0.00001646124,0.00004176689,0.0004978157,0.00005341354,0.0007265622,0.9848288,0.0002618119,0.008986767,0.00001191879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8958349,0.001687557,0.08902279,0.00009766071,0.0002021665,0.001326523,0.003662043,0.0004330045,0.007733376],"genre_scores_gemma":[0.8674343,0.002479908,0.1097797,0.0002891494,0.00005873008,0.001466273,0.008790133,0.000234973,0.009466807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755098,"threshold_uncertainty_score":0.005871356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117190061939964,"score_gpt":0.318938051397189,"score_spread":0.2877661507777894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}