{"id":"W2796408284","doi":"10.3389/fimmu.2018.00654","title":"Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy","year":2018,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Acadia University; Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Immunogenic cell death; Epigenetics; Immunotherapy; Cancer; Immune system; Cancer immunotherapy; Immunology; Tumor microenvironment; Cancer research; Cancer cell; Epigenetic therapy; Decitabine; Biology; Calreticulin; Medicine; DNA methylation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002704171,0.0004082537,0.001174437,0.0003213763,0.00005944549,0.00001124575,0.0005698808,0.0007140726,0.00002444347],"category_scores_gemma":[0.00004768603,0.0004012995,0.0003999918,0.0002462483,0.0001025493,0.00000394305,0.0001411366,0.000172352,0.00000258212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066422,"about_ca_system_score_gemma":0.0003549968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007470124,"about_ca_topic_score_gemma":0.000008044462,"domain_scores_codex":[0.9978911,0.0001731142,0.0008044644,0.0005862653,0.00009088832,0.0004541761],"domain_scores_gemma":[0.9986468,0.00004160562,0.0004836477,0.0006615524,0.0001309326,0.00003544409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001392125,0.0003642278,0.0002943721,0.008490964,0.003595016,0.000005023294,0.0006880473,0.0004671619,0.1018224,0.00007376988,0.05157631,0.8312305],"study_design_scores_gemma":[0.0006605998,0.0004918992,0.00002951732,0.0009173992,0.0002401448,0.000008735578,0.0000433842,0.00001270064,0.01162535,0.00005727392,0.9854631,0.0004498895],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001654788,0.97155,0.02406008,0.00002433033,0.001510186,0.001066241,0.00006244637,0.00001286887,0.00005901491],"genre_scores_gemma":[0.0004503632,0.9847702,0.01261767,0.00008344593,0.0003191958,0.00044993,0.0003728054,0.0001369403,0.0007994194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9338868,"threshold_uncertainty_score":0.9998439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779349235332289,"score_gpt":0.3049119599989575,"score_spread":0.2771184676456346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}