{"id":"W2796408284","doi":"10.3389/fimmu.2018.00654","title":"Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy","year":2018,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Acadia University; Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Immunogenic cell death; Epigenetics; Immunotherapy; Cancer; Immune system; Cancer immunotherapy; Immunology; Tumor microenvironment; Cancer research; Cancer cell; Epigenetic therapy; Decitabine; Biology; Calreticulin; Medicine; DNA methylation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004108687,0.0006350221,0.0006746128,0.001399404,0.0003369811,0.0009059168,0.0005992039,0.001159086,0.002908897],"category_scores_gemma":[0.000437638,0.0001997472,0.0002956757,0.001160178,0.0006198018,0.00147957,0.0006758631,0.002009427,0.00165131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007002922,"about_ca_system_score_gemma":0.000868561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004148151,"about_ca_topic_score_gemma":0.001001779,"domain_scores_codex":[0.9998928,0.00001963009,0.00001490973,0.00002153685,0.00003969258,0.00001141196],"domain_scores_gemma":[0.9998166,0.00009298425,0.0000189811,0.000007456257,0.00004319767,0.00002088893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005743043,0.00006034854,0.00017258,0.01129291,0.00005333049,0.0003181592,0.0001400895,0.0003567325,0.006105348,0.01613203,0.03695545,0.9283556],"study_design_scores_gemma":[0.000007654469,0.00004616698,0.0003818625,0.001104439,0.00002833206,0.001017354,0.00005211362,0.00007565843,0.0008024233,0.003459177,0.9930124,0.00001243534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001565111,0.9963712,0.0003721883,0.0005958003,0.0005670527,0.000005737356,0.00001487765,0.00001018562,0.001906578],"genre_scores_gemma":[0.001228805,0.9961339,0.0003258223,0.0003922461,0.0003964287,0.000009492551,0.00002704065,0.00000292,0.001483276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002908897,"threshold_uncertainty_score":0.009731174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779349235332289,"score_gpt":0.3049119599989575,"score_spread":0.2771184676456346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}