{"id":"W2796415375","doi":"10.1016/bs.ircmb.2018.02.005","title":"The Dynamics of GPCR Oligomerization and Their Functional Consequences","year":2018,"lang":"en","type":"review","venue":"International review of cell and molecular biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Biology; Allosteric regulation; Computational biology; Function (biology); PDZ domain; Obligate; Receptor; Viewpoints; Signal transduction; Neuroscience; Cell biology; Biochemistry; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003355887,0.0001933868,0.000510463,0.00004280736,0.00004202586,0.000008989256,0.0002128609,0.000177134,0.00002642227],"category_scores_gemma":[0.0001230803,0.0001143512,0.0002055983,0.00005098687,0.0003969352,0.000001977623,0.0001415735,0.00007003666,7.9644e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007652749,"about_ca_system_score_gemma":0.000111332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003950676,"about_ca_topic_score_gemma":0.000002209445,"domain_scores_codex":[0.9989108,0.0001533513,0.0004936541,0.0002664608,0.00007627629,0.00009949863],"domain_scores_gemma":[0.9990308,0.00005979844,0.0005062739,0.0001654524,0.0002053779,0.00003227871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002711968,0.00004357393,0.000008860113,0.02186626,0.0006855479,0.000001230827,0.000009165114,3.159411e-7,0.1233789,0.04035715,0.0002753561,0.8133465],"study_design_scores_gemma":[0.00008900079,0.0001934828,4.633569e-7,0.005633762,0.0001194834,0.00004577249,0.00001077294,0.0000144137,0.01664793,0.0009873395,0.9761068,0.0001508416],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001608875,0.9899602,0.008674292,0.00007941281,0.0002953899,0.0002352812,0.0001058178,0.000001716683,0.0004869889],"genre_scores_gemma":[0.0008832266,0.9977256,0.000240006,0.0001113601,0.00008370297,0.00002647728,0.0008188098,0.00001366603,0.00009713409],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9758314,"threshold_uncertainty_score":0.4663107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341614995168997,"score_gpt":0.2899491625684791,"score_spread":0.2765330126167891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}