{"id":"W2796416879","doi":"10.1080/10428194.2018.1452208","title":"Single-agent panobinostat for relapsed/refractory diffuse large B-cell lymphoma: clinical outcome and correlation with genomic data. A phase 2 study of the Fondazione Italiana Linfomi","year":2018,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; McGill University; Jewish General Hospital","funders":"","keywords":"Panobinostat; Medicine; Internal medicine; Refractory (planetary science); Diffuse large B-cell lymphoma; Lymphoma; Oncology; Overall survival; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008909448,0.0009433012,0.001617982,0.0002625803,0.0007793453,0.000151221,0.0006214885,0.0005367453,0.00002315062],"category_scores_gemma":[0.0003049234,0.0006390871,0.0003333348,0.0004921407,0.0008089765,0.0004720314,0.0007724037,0.0001350845,0.00003033736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003729459,"about_ca_system_score_gemma":0.002414026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007526595,"about_ca_topic_score_gemma":0.000392228,"domain_scores_codex":[0.994194,0.0002988363,0.00196142,0.001738248,0.0008187348,0.000988787],"domain_scores_gemma":[0.9944789,0.0008977726,0.001125381,0.0024537,0.0003797921,0.0006644626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01299142,0.0582104,0.7177869,0.0006328418,0.001859062,0.0003935506,0.00479799,0.000005834992,0.001758851,0.0002918248,0.006111826,0.1951595],"study_design_scores_gemma":[0.3578576,0.01460962,0.5742953,0.0003685234,0.003302241,0.000599061,0.002673231,0.006991515,0.001555238,0.00003856319,0.03674707,0.0009619908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925106,0.001587274,0.0002097904,0.0001582072,0.0008334468,0.003536937,0.0005312909,0.0001361378,0.0004963385],"genre_scores_gemma":[0.9954748,0.0003902204,0.0007192227,0.001034501,0.0005268779,0.0002398202,0.0004206844,0.0001637891,0.001030112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3448662,"threshold_uncertainty_score":0.999606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04424755085223389,"score_gpt":0.3179352172130256,"score_spread":0.2736876663607918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}