{"id":"W2796416879","doi":"10.1080/10428194.2018.1452208","title":"Single-agent panobinostat for relapsed/refractory diffuse large B-cell lymphoma: clinical outcome and correlation with genomic data. A phase 2 study of the Fondazione Italiana Linfomi","year":2018,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; McGill University; Jewish General Hospital","funders":"","keywords":"Panobinostat; Medicine; Internal medicine; Refractory (planetary science); Diffuse large B-cell lymphoma; Lymphoma; Oncology; Overall survival; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008520948,0.0005270218,0.0007754992,0.0003543441,0.0001579202,0.0002475381,0.0002480943,0.0004312083,0.0007442041],"category_scores_gemma":[0.0005684919,0.0001689911,0.0003612453,0.000262802,0.0002924856,0.0002664608,0.0001569828,0.0005484128,0.0002071265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057658,"about_ca_system_score_gemma":0.0002294864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004018925,"about_ca_topic_score_gemma":0.0009636791,"domain_scores_codex":[0.999768,0.0001224609,0.00001403392,0.00003459002,0.00003238486,0.00002851768],"domain_scores_gemma":[0.9996661,0.0000920707,0.00006936089,0.00002442764,0.00001913408,0.0001288416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1847512,0.02134996,0.2135146,0.0009570384,0.002076231,0.001879753,0.0005761817,0.006711284,0.1592012,0.0001593444,0.001804745,0.4070185],"study_design_scores_gemma":[0.04297867,0.5357233,0.3850136,0.00006265241,0.001264264,0.00357078,0.0001529784,0.005231443,0.02056957,0.0002081476,0.005174876,0.00004968512],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997389,0.001761908,0.0001940351,0.00005758818,0.00000912661,0.0001324104,0.0001271195,0.00001549811,0.0003133326],"genre_scores_gemma":[0.9977472,0.0007480895,0.0004382491,0.000115682,0.00002977494,0.0001039852,0.0005276235,0.000005388273,0.0002839626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008520948,"threshold_uncertainty_score":0.00450635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04424755085223389,"score_gpt":0.3179352172130256,"score_spread":0.2736876663607918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}