{"id":"W2796418582","doi":"10.1200/po.17.00125","title":"Fundamental Concepts in the Application of Plasma Genotyping (Liquid Biopsy) to <i>EGFR</i> Mutation Detection in Non–Small-Cell Lung Cancer","year":2018,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Genotyping; T790M; KRAS; Liquid biopsy; Lung cancer; Epidermal growth factor receptor; Biomarker; Medicine; Oncology; Cancer; Biology; Cancer research; Internal medicine; Genotype; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005132076,0.0002936881,0.001063734,0.0005272734,0.00006905031,0.00001317197,0.0002119006,0.0004336662,0.00004931778],"category_scores_gemma":[0.00005959829,0.0002073675,0.0001827895,0.0008623157,0.00006509551,0.0000604349,0.0000675886,0.0003314207,0.00004945291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002235151,"about_ca_system_score_gemma":0.0008176902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008137145,"about_ca_topic_score_gemma":0.00202833,"domain_scores_codex":[0.9977264,0.000272919,0.0009463942,0.0005397274,0.000242114,0.0002723824],"domain_scores_gemma":[0.9984252,0.0004197571,0.0005626933,0.0003789699,0.0001353872,0.00007802971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002964312,0.000440402,0.00006900024,0.002001749,0.00008072353,0.00002309771,0.002314896,0.00003883858,0.0003991113,0.000009024277,0.0001485159,0.9941782],"study_design_scores_gemma":[0.003395241,0.002393661,0.000495147,0.006085671,0.001620707,0.0001652817,0.0006073366,0.0005991459,0.0006543496,0.00001497291,0.9836447,0.0003238226],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06815306,0.9095191,0.004891435,0.0002997624,0.00118186,0.01223783,0.0001100292,0.00004109145,0.003565768],"genre_scores_gemma":[0.07927402,0.9104766,0.001870272,0.0004193619,0.0004885339,0.006730639,0.0003693843,0.00008431729,0.0002868843],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938544,"threshold_uncertainty_score":0.8456202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03265072183519806,"score_gpt":0.4358843568916937,"score_spread":0.4032336350564956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}