{"id":"W2796524813","doi":"10.1016/j.neuroscience.2018.03.033","title":"Transcription Factors in Regulatory and Protein Subnetworks during Generation of Neural Stem Cells and Neurons from Direct Reprogramming of Non-fibroblastic Cell Sources","year":2018,"lang":"en","type":"article","venue":"Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Reprogramming; SOX2; Biology; Transcription factor; Cell biology; KLF4; Homeobox protein NANOG; Gene regulatory network; HEK 293 cells; Cell type; Neural stem cell; Gene; Induced pluripotent stem cell; Computational biology; Stem cell; Cell; Gene expression; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223165,0.0001732846,0.0001386378,0.0001726879,0.0001632013,0.0003161528,0.0002043192,0.0001413345,0.001775256],"category_scores_gemma":[0.0001176291,0.0001549827,0.0002604041,0.0001526645,0.0001602039,0.000210661,0.0002904861,0.0004339437,0.0003890865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386716,"about_ca_system_score_gemma":0.0002227447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065562,"about_ca_topic_score_gemma":0.001837209,"domain_scores_codex":[0.9998754,0.000009147949,0.000008619211,0.00004624273,0.00003507443,0.00002548545],"domain_scores_gemma":[0.9999412,0.00001210381,0.00001539957,0.000008359933,0.00000652355,0.00001640699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009439366,0.000007690815,0.0002475314,0.00001416365,0.000004574897,0.00003241881,0.0000163813,0.00007458386,0.9976827,0.000328399,0.00002843688,0.001468758],"study_design_scores_gemma":[0.00001298813,0.00004402312,0.007767339,0.000007630406,0.00003416187,0.0001772843,0.00003960625,0.001170029,0.986594,0.0002719234,0.003877603,0.000003528579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866198,0.001238165,0.007914643,0.0000996412,0.00003905051,0.00002281831,0.0006755925,0.00007499238,0.003315362],"genre_scores_gemma":[0.9898136,0.0004505937,0.002615562,0.00006309417,0.00000809574,0.00002579538,0.0009859179,0.00004453379,0.005992777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775256,"threshold_uncertainty_score":0.005938828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921248619831684,"score_gpt":0.2324676961276061,"score_spread":0.2132552099292893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}