{"id":"W2796582438","doi":"10.1056/nejmoa1801005","title":"Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6613,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Merck","keywords":"Pembrolizumab; Chemotherapy; Lung cancer; Medicine; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002149055,0.0003984757,0.001414144,0.0003414786,0.0002174911,0.000287315,0.0003589094,0.0004797927,0.001910802],"category_scores_gemma":[0.003012876,0.0002691487,0.0006203543,0.0003850163,0.0004140425,0.0003184328,0.0002967295,0.001055769,0.0002772533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006237773,"about_ca_system_score_gemma":0.000704916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000626358,"about_ca_topic_score_gemma":0.001238239,"domain_scores_codex":[0.9988425,0.0007904429,0.00008557749,0.0001211674,0.0001068308,0.00005347223],"domain_scores_gemma":[0.9989343,0.0005345494,0.0002222684,0.00005647919,0.0000332304,0.000219058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7994949,0.009483032,0.005831027,0.001753233,0.001320189,0.000128146,0.000102501,0.00366938,0.007810586,0.0002942646,0.0008574247,0.1692553],"study_design_scores_gemma":[0.4999373,0.4562846,0.02921075,0.0002105433,0.001430111,0.0003990839,0.00003204459,0.004560297,0.002625062,0.0006569016,0.004622958,0.00003031307],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886108,0.007852877,0.0006011855,0.0003344637,0.000191094,0.001165916,0.0001201286,0.00002081585,0.001102773],"genre_scores_gemma":[0.9942865,0.003191142,0.0008111283,0.0001862655,0.0001595917,0.000713174,0.0001116721,0.000003669425,0.0005369978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149055,"threshold_uncertainty_score":0.01136547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975310630683914,"score_gpt":0.3120918999598457,"score_spread":0.2923387936530065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}