{"id":"W2796687384","doi":"10.1101/303537","title":"Targeting Human Retinoblastoma Binding Protein 4 (RBBP4) and 7 (RBBP7)","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Innovative Medicines Initiative; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Wellcome Trust; Novartis; Genome Canada; European Federation of Pharmaceutical Industries and Associations; Merck; Bayer; Pfizer","keywords":"Histone; Histone H3; Computational biology; Biology; PRC2; Binding site; Chemistry; Genetics; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546114,0.0004288122,0.0003783152,0.0004798268,0.0002705184,0.0003530415,0.0003838912,0.0004260797,0.004125187],"category_scores_gemma":[0.0001423758,0.0001816059,0.000461583,0.0003102761,0.0001997128,0.0001355834,0.0003297026,0.000535781,0.002902694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006192385,"about_ca_system_score_gemma":0.000390524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365211,"about_ca_topic_score_gemma":0.001838371,"domain_scores_codex":[0.9997151,0.00003612002,0.00001559517,0.00004341278,0.0001198976,0.00006981745],"domain_scores_gemma":[0.999953,0.000008394272,0.000007963758,0.000006265782,0.00001178616,0.00001252595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002658235,0.00008138145,0.000445414,0.0001943468,0.00004068411,0.0001188369,0.00001644621,0.0005869266,0.9810807,0.0007280898,0.001958196,0.01448315],"study_design_scores_gemma":[0.00002484729,0.0001784316,0.0008275255,0.000008692144,0.00003018552,0.0001765115,0.00001126183,0.0009010042,0.975575,0.0001115111,0.02214945,0.000005575022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8625391,0.03533636,0.05369246,0.001280185,0.0006868239,0.0008485921,0.007540473,0.00231363,0.03576229],"genre_scores_gemma":[0.8858504,0.00924013,0.0393637,0.0005005376,0.00006953993,0.0004056739,0.009717978,0.0002397726,0.05461213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004125187,"threshold_uncertainty_score":0.01380008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249184746808287,"score_gpt":0.2257971303596421,"score_spread":0.2133052828915592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}