{"id":"W2796765042","doi":"10.1089/hum.2018.018","title":"CRISPR/Cas9 Inhibits Multiple Steps of HIV-1 Infection","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cas9; CRISPR; Biology; Provirus; DNA; Plasmid; Virology; Gene; Genome editing; Molecular biology; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009178354,0.0001196112,0.0001050741,0.00004633166,0.00007143304,0.000008266715,0.00008666898,0.00008952724,0.00007363362],"category_scores_gemma":[0.00000926161,0.0001180759,0.00007154093,0.00006090969,0.00006859566,0.000002109447,0.00003706474,0.0000428253,0.0000166164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005832134,"about_ca_system_score_gemma":0.00001328705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003166578,"about_ca_topic_score_gemma":0.0001073565,"domain_scores_codex":[0.9993758,0.00002286454,0.0001602795,0.0002047722,0.00007825856,0.0001580885],"domain_scores_gemma":[0.9995401,0.00000380852,0.00004927746,0.0002919091,0.00007264589,0.00004224159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000397827,0.00004812753,0.00625038,0.000006804036,0.00003310194,2.034906e-7,0.0001236918,0.0000866666,0.988974,0.0000157719,0.0008981383,0.003523315],"study_design_scores_gemma":[0.0006989019,0.0005479515,0.02260971,0.000005844125,0.000004429381,0.000004865336,0.000008925784,0.00005324844,0.9529883,0.00004384126,0.0229022,0.0001318228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875802,0.0006251067,0.01066137,0.00001372515,0.0001539913,0.0001321252,0.000007566878,0.00001968569,0.0008061891],"genre_scores_gemma":[0.9980102,0.0003804776,0.0004871532,0.00006077725,0.0005971376,0.00001067393,0.00004983552,0.0000259158,0.0003778735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03598575,"threshold_uncertainty_score":0.4814994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779815648448066,"score_gpt":0.3188524716163099,"score_spread":0.3010543151318292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}