{"id":"W2796765042","doi":"10.1089/hum.2018.018","title":"CRISPR/Cas9 Inhibits Multiple Steps of HIV-1 Infection","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cas9; CRISPR; Biology; Provirus; DNA; Plasmid; Virology; Gene; Genome editing; Molecular biology; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865748,0.0004417097,0.0005246546,0.0002528807,0.0002636575,0.0005417505,0.0004346026,0.0005371924,0.001508065],"category_scores_gemma":[0.0002236092,0.0002308727,0.0004184732,0.0001189364,0.0002835861,0.0002205839,0.0004052575,0.001002521,0.0006169663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003873686,"about_ca_system_score_gemma":0.0003592363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007365391,"about_ca_topic_score_gemma":0.001065004,"domain_scores_codex":[0.999622,0.00004597363,0.00004361888,0.00008456555,0.0001354928,0.00006837006],"domain_scores_gemma":[0.999869,0.00003153003,0.00002933837,0.00002550029,0.00001874245,0.00002595933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009889042,0.00003945781,0.0002231895,0.00008086742,0.00001034951,0.000107257,0.0000142371,0.0003983823,0.9924124,0.0004069666,0.0001550233,0.006053078],"study_design_scores_gemma":[0.000009464348,0.0001152182,0.0007389098,0.000008683367,0.0000107339,0.000232795,0.000008594669,0.001950046,0.9929689,0.00008696035,0.00386387,0.000005753077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9324154,0.006850868,0.0434897,0.0003322352,0.0002605931,0.0003026683,0.0008159258,0.001225247,0.01430735],"genre_scores_gemma":[0.9675529,0.002008935,0.0232804,0.00009006842,0.00001919149,0.0001087929,0.0004150321,0.00006345002,0.006461194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508065,"threshold_uncertainty_score":0.005044937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779815648448066,"score_gpt":0.3188524716163099,"score_spread":0.3010543151318292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}