{"id":"W2796827135","doi":"10.3233/jad-170887","title":"Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer’s Disease Pathogenesis","year":2018,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Pathogenesis; Cerebrospinal fluid; Dementia; Stage (stratigraphy); Disease; Immune system; Medicine; Cohort; Pathology; Alzheimer's disease; Neuroimaging; Amyloid (mycology); Immunology; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005199842,0.0002457169,0.0004000544,0.000353106,0.0001840804,0.00004886565,0.0002846964,0.00005248635,0.0005763849],"category_scores_gemma":[0.0006179919,0.0002086567,0.0003226755,0.0004887392,0.0001783336,0.0005416704,0.0000562836,0.000163071,0.00002416205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004071918,"about_ca_system_score_gemma":0.0005520683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003630687,"about_ca_topic_score_gemma":0.000001557292,"domain_scores_codex":[0.9966085,0.000420706,0.001049228,0.0003219687,0.001331535,0.0002680573],"domain_scores_gemma":[0.9963287,0.0001341627,0.001897675,0.000349844,0.0007750818,0.0005145909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003206362,0.0004930205,0.006235132,0.00003542897,0.0002127333,0.00009196941,0.00006053253,0.000414002,0.9869725,0.0007272301,0.0008453185,0.0007057371],"study_design_scores_gemma":[0.001330564,0.0006689808,0.1297523,0.00007196084,0.0009188681,0.00001729495,0.00002270081,0.0008678554,0.865159,0.00009894568,0.0008697395,0.0002216951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960583,0.0007273956,0.0005916988,0.000887409,0.0008699938,0.0003385089,0.0002766503,0.00003605784,0.0002140241],"genre_scores_gemma":[0.9982541,0.000136149,0.0005916937,0.0003600298,0.0002738415,0.000007772608,0.00000591914,0.00004148749,0.0003290612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1235172,"threshold_uncertainty_score":0.8508775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02903315753240096,"score_gpt":0.2672312346710374,"score_spread":0.2381980771386364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}