{"id":"W2796900308","doi":"10.1158/1535-7163.targ-17-lb-a12","title":"Abstract LB-A12: Results from the phase 3 study ARIEL3: mutations in non-<i>BRCA</i> homologous recombination repair genes confer sensitivity to maintenance treatment with the PARP inhibitor rucaparib in patients with recurrent platinum-sensitive high-grade ovarian carcinoma","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"PARP inhibitor; Olaparib; Oncology; Medicine; Internal medicine; BRCA mutation; Cancer research; Homologous recombination; Ovarian cancer; Cancer; Genetics; Biology; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003599414,0.001067843,0.002371783,0.000364119,0.0004819969,0.0009768389,0.0009414586,0.001354468,0.00398617],"category_scores_gemma":[0.001827417,0.0004678584,0.002740423,0.0004557106,0.0009533542,0.0007777168,0.0003562808,0.003619549,0.0008156216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007882069,"about_ca_system_score_gemma":0.001515514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317674,"about_ca_topic_score_gemma":0.003065898,"domain_scores_codex":[0.9986761,0.0008049636,0.00008917903,0.0001621832,0.0001141781,0.0001533701],"domain_scores_gemma":[0.997974,0.0004843644,0.0004165281,0.0003032385,0.000181369,0.0006405145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8971577,0.0267083,0.007896012,0.0004020743,0.002002944,0.000133009,0.0001367329,0.000593278,0.02850419,0.00005977212,0.002213665,0.03419221],"study_design_scores_gemma":[0.5403723,0.4125307,0.03728901,0.00004189258,0.001734564,0.0002694722,0.00006980529,0.0006675007,0.005168164,0.0001357477,0.001669604,0.00005124794],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937145,0.00169694,0.000419544,0.000396434,0.00007067528,0.001016322,0.001622736,0.0001050797,0.0009577236],"genre_scores_gemma":[0.9926308,0.00065816,0.0009619448,0.0007406571,0.0001240522,0.0008025466,0.002841045,0.00004606548,0.001194617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00398617,"threshold_uncertainty_score":0.01903576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396565789102692,"score_gpt":0.2962446725173956,"score_spread":0.2722790146263686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}