{"id":"W2796900308","doi":"10.1158/1535-7163.targ-17-lb-a12","title":"Abstract LB-A12: Results from the phase 3 study ARIEL3: mutations in non-<i>BRCA</i> homologous recombination repair genes confer sensitivity to maintenance treatment with the PARP inhibitor rucaparib in patients with recurrent platinum-sensitive high-grade ovarian carcinoma","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"PARP inhibitor; Olaparib; Oncology; Medicine; Internal medicine; BRCA mutation; Cancer research; Homologous recombination; Ovarian cancer; Cancer; Genetics; Biology; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004717835,0.0004628383,0.000521417,0.0001426611,0.000234668,0.00005787578,0.0001306342,0.0001278865,0.00001534014],"category_scores_gemma":[0.000025696,0.0002751895,0.00008718934,0.0006860666,0.0003469781,0.00009366809,0.00003563421,0.0004134091,0.000007598175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00113005,"about_ca_system_score_gemma":0.0004184958,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006875784,"about_ca_topic_score_gemma":0.01451719,"domain_scores_codex":[0.9970494,0.0004626602,0.0005853594,0.000802537,0.0005898682,0.0005101984],"domain_scores_gemma":[0.9978108,0.000337227,0.0003307503,0.0008558032,0.0005481087,0.0001173592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1179481,0.02916081,0.4868185,0.00006877433,0.005160141,0.003303953,0.1629383,0.004693659,0.05450032,0.0002442491,0.001387684,0.1337756],"study_design_scores_gemma":[0.05289588,0.009961769,0.8896772,0.0004670092,0.0004609317,0.00001555631,0.002962737,0.0009610829,0.04050595,0.00009638089,0.001401775,0.0005937146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880126,0.0001506429,0.001089037,0.005710451,0.0003209566,0.003988193,0.0005802157,0.00005948474,0.00008840654],"genre_scores_gemma":[0.9954149,0.00003745328,0.0004851253,0.002874085,0.0001931453,0.0006366972,0.0002564966,0.00007119979,0.00003087365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4028587,"threshold_uncertainty_score":0.99997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396565789102692,"score_gpt":0.2962446725173956,"score_spread":0.2722790146263686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}