{"id":"W2796952555","doi":"10.1101/304022","title":"S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca <sup>2+</sup> entry","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Nantong University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Nitric oxide; Cell biology; Chemistry; S-Nitrosylation; Nitrosylation; HEK 293 cells; Nitric oxide synthase; Biophysics; Biochemistry; Biology; Cysteine; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006697284,0.0008655962,0.0008357849,0.0005538365,0.0003417783,0.00022801,0.0008924248,0.0008235183,0.0003424974],"category_scores_gemma":[0.001451011,0.0008645141,0.0002542152,0.001205566,0.0004564665,0.0003281112,0.0006913018,0.001139715,0.0002492736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029077,"about_ca_system_score_gemma":0.000714909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001080398,"about_ca_topic_score_gemma":3.49531e-7,"domain_scores_codex":[0.9947985,0.0006189353,0.001027123,0.001710938,0.0009861559,0.0008583521],"domain_scores_gemma":[0.9968297,0.0002649461,0.0007854781,0.0009725586,0.0006918043,0.0004555174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168938,0.0003522633,0.000514715,0.0002587886,0.00003708513,0.00002222266,0.00001974672,0.002106074,0.9912727,0.00005382998,0.005244161,0.000001554387],"study_design_scores_gemma":[0.0007150728,0.000106973,0.001824917,0.0003318931,0.00008233923,6.594816e-8,0.0000047875,0.01259148,0.9808616,0.000001755016,0.002634275,0.0008448533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948708,0.000341766,0.0005284607,0.0001164099,0.00128556,0.000950243,0.001509673,0.0003738588,0.00002322758],"genre_scores_gemma":[0.9978606,0.0002995723,0.0004436725,0.0003688716,0.0006654665,0.0001091894,0.000003014936,0.0002002484,0.00004932786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01048541,"threshold_uncertainty_score":0.9993806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162003530858554,"score_gpt":0.2231707903190095,"score_spread":0.2069704372331541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}