{"id":"W2796952555","doi":"10.1101/304022","title":"S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca <sup>2+</sup> entry","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Nantong University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Nitric oxide; Cell biology; Chemistry; S-Nitrosylation; Nitrosylation; HEK 293 cells; Nitric oxide synthase; Biophysics; Biochemistry; Biology; Cysteine; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343498,0.0001947818,0.0002164349,0.00007065564,0.00008010878,0.0001301838,0.0001581941,0.0001406864,0.00109071],"category_scores_gemma":[0.000130206,0.00006330793,0.000143954,0.00005417574,0.0002520577,0.0001069468,0.0001402107,0.0002403702,0.0002506263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570744,"about_ca_system_score_gemma":0.0002192651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005041304,"about_ca_topic_score_gemma":0.000831264,"domain_scores_codex":[0.9999311,0.00001440367,0.000009045463,0.00001185957,0.00001285976,0.00002073542],"domain_scores_gemma":[0.999947,0.00001072412,0.0000146063,0.000006958994,0.000005437365,0.00001524343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000286861,0.00003393648,0.0001370304,0.00004131875,0.000007254237,0.00002824205,0.00001313897,0.00005740558,0.99847,0.00009420743,0.00004936024,0.0007812],"study_design_scores_gemma":[0.00002128841,0.0002167185,0.002159762,0.000004246328,0.000008501605,0.00007280771,0.00001609642,0.0007655697,0.9957398,0.00003918197,0.0009540503,0.000002006692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976493,0.0007823005,0.0005950745,0.00006113781,0.00002304463,0.000008707771,0.0001084666,0.00002583694,0.0007461814],"genre_scores_gemma":[0.9964746,0.0006243623,0.0009993603,0.00003770475,0.00000987805,0.0000174607,0.0002584167,0.00001310026,0.001565221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109071,"threshold_uncertainty_score":0.003648758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162003530858554,"score_gpt":0.2231707903190095,"score_spread":0.2069704372331541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}