{"id":"W2797047348","doi":"10.1016/j.biopsych.2018.09.009","title":"Glutamatergic Neurometabolite Levels in Patients With Ultra-Treatment-Resistant Schizophrenia: A Cross-Sectional 3T Proton Magnetic Resonance Spectroscopy Study","year":2018,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Japan Society for the Promotion of Science; GlaxoSmithKline; HLS Therapeutics; Shionogi; Takeda Canada; Daiichi-Sankyo; Ontario Mental Health Foundation; W. Garfield Weston Foundation; Ontario Ministry of Economic Development and Innovation; Mitsukoshi Health and Welfare Foundation; National Alliance for Research on Schizophrenia and Depression; Otsuka Pharmaceutical; Centre for Addiction and Mental Health; Naito Foundation; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Mitsubishi Tanabe Pharma Corporation; Consejo Nacional de Ciencia y Tecnología; Janssen Pharmaceuticals; Instituto de Ciencia y Tecnología del Distrito Federal; Eli Lilly and Company; Dainippon Sumitomo Pharma; Takeda Science Foundation; Meso Scale Diagnostics; Pfizer; Japan Research Foundation for Clinical Pharmacology","keywords":"Glutamatergic; Glutamate receptor; Anterior cingulate cortex; Dorsolateral prefrontal cortex; Schizophrenia (object-oriented programming); Glutamine; Internal medicine; Antipsychotic; Medicine; Clozapine; Prefrontal cortex; Endocrinology; Psychology; Neuroscience; Psychiatry; Chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008182433,0.0002570082,0.0003212643,0.00009073979,0.0001478812,0.0000281941,0.0001302069,0.0001202759,0.0001689667],"category_scores_gemma":[0.00001845951,0.0001557406,0.00006419577,0.0004070977,0.0002517467,0.00005423322,0.00002562719,0.0001856787,0.00003619216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008749981,"about_ca_system_score_gemma":0.0000694976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001925667,"about_ca_topic_score_gemma":0.00002545111,"domain_scores_codex":[0.9983779,0.00004994825,0.0003798627,0.0006409031,0.0001973472,0.0003540659],"domain_scores_gemma":[0.9992629,0.00001921603,0.0000996696,0.0004058453,0.00009857403,0.0001137568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003304071,0.00260866,0.9911332,0.000007604505,0.000006387082,0.000004098807,0.00001522392,5.477925e-7,0.001898131,0.0005457776,0.00001245908,0.0004638482],"study_design_scores_gemma":[0.005150616,0.01425176,0.9763459,0.00003193343,0.00001499007,0.000006240168,0.00001266368,0.000002856254,0.000704363,0.001436904,0.001865849,0.0001759471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953502,0.0003335697,0.0002532949,0.0001170712,0.0001217751,0.003181957,0.00008894496,0.0001646904,0.0003884792],"genre_scores_gemma":[0.9809627,0.0000282388,0.01771653,0.0001767935,0.0002489346,0.000690422,0.00003018913,0.00002207973,0.0001241087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01746324,"threshold_uncertainty_score":0.6350916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540637533011168,"score_gpt":0.3247327633765377,"score_spread":0.299326388046426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}