{"id":"W2797047348","doi":"10.1016/j.biopsych.2018.09.009","title":"Glutamatergic Neurometabolite Levels in Patients With Ultra-Treatment-Resistant Schizophrenia: A Cross-Sectional 3T Proton Magnetic Resonance Spectroscopy Study","year":2018,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Japan Society for the Promotion of Science; GlaxoSmithKline; HLS Therapeutics; Shionogi; Takeda Canada; Daiichi-Sankyo; Ontario Mental Health Foundation; W. Garfield Weston Foundation; Ontario Ministry of Economic Development and Innovation; Mitsukoshi Health and Welfare Foundation; National Alliance for Research on Schizophrenia and Depression; Otsuka Pharmaceutical; Centre for Addiction and Mental Health; Naito Foundation; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Mitsubishi Tanabe Pharma Corporation; Consejo Nacional de Ciencia y Tecnología; Janssen Pharmaceuticals; Instituto de Ciencia y Tecnología del Distrito Federal; Eli Lilly and Company; Dainippon Sumitomo Pharma; Takeda Science Foundation; Meso Scale Diagnostics; Pfizer; Japan Research Foundation for Clinical Pharmacology","keywords":"Glutamatergic; Glutamate receptor; Anterior cingulate cortex; Dorsolateral prefrontal cortex; Schizophrenia (object-oriented programming); Glutamine; Internal medicine; Antipsychotic; Medicine; Clozapine; Prefrontal cortex; Endocrinology; Psychology; Neuroscience; Psychiatry; Chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278699,0.000400394,0.0004295464,0.0004194785,0.0005930727,0.0005604006,0.0002016478,0.0006568744,0.001006446],"category_scores_gemma":[0.0006673558,0.0004196305,0.0003221805,0.0003785314,0.0002599571,0.0004496383,0.0002240356,0.0005915973,0.0002555455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003424124,"about_ca_system_score_gemma":0.0002474373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005111856,"about_ca_topic_score_gemma":0.00632655,"domain_scores_codex":[0.9998878,0.00002492701,0.00001507665,0.00003268408,0.00002168819,0.00001786716],"domain_scores_gemma":[0.9996843,0.00004872369,0.0001114374,0.00002383049,0.00004326183,0.00008843291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002051705,0.0007905422,0.9806188,0.00003261412,0.0002750349,0.00112107,0.0005991572,0.0000793096,0.01105521,0.00003996355,0.000125118,0.003211583],"study_design_scores_gemma":[0.00003628983,0.0005365713,0.9974412,0.000003068969,0.0001106409,0.0009592118,0.0003086966,0.0001304959,0.0003379945,0.00002188449,0.0001053978,0.000008703082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996153,0.00008816038,0.00003523207,0.00002398683,0.000002174908,0.000005766311,0.00005542639,0.000001955034,0.0001719574],"genre_scores_gemma":[0.9995207,0.00007604335,0.0000670344,0.00004337839,0.000003955213,0.000004899786,0.0001139506,0.000001855394,0.0001683009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005111856,"threshold_uncertainty_score":0.0101642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540637533011168,"score_gpt":0.3247327633765377,"score_spread":0.299326388046426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}