{"id":"W2797097787","doi":"10.1177/2472555217750871","title":"Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Cancer Institute; Purdue University","keywords":"Computational biology; Peptidomimetic; DNA; Robustness (evolution); Biochemistry; Chemistry; Biology; Peptide; Combinatorial chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00280597,0.0008051163,0.0006698476,0.0004963732,0.000295259,0.0008542707,0.0004768875,0.0004700148,0.0006138222],"category_scores_gemma":[0.004527248,0.0004099352,0.0003754187,0.0006095137,0.0005444076,0.0003002317,0.0005762123,0.0006528703,0.0003037172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005057742,"about_ca_system_score_gemma":0.0003256062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655571,"about_ca_topic_score_gemma":0.00114677,"domain_scores_codex":[0.9957618,0.001717897,0.000424077,0.0004726359,0.001317877,0.0003056687],"domain_scores_gemma":[0.9964291,0.002193782,0.0005893667,0.0002640983,0.0003653758,0.0001582392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100279,0.00003599362,0.0005734743,0.00002751582,0.00001942141,0.00001337081,0.00002876127,0.0006100042,0.9969132,0.00003153182,0.00001542584,0.001631121],"study_design_scores_gemma":[0.000004260288,0.0002749885,0.0009057982,0.000001848587,0.00001071238,0.00004058399,0.00001350136,0.001188043,0.9973341,0.00001667485,0.0002044516,0.000005021368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607873,0.0007217912,0.03661507,0.00009861685,0.00002600562,0.0001384006,0.0002929303,0.000183359,0.001136525],"genre_scores_gemma":[0.9658993,0.0008958945,0.02972227,0.0001080685,0.00001930012,0.0002219576,0.0009160329,0.00009101698,0.002126105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00280597,"threshold_uncertainty_score":0.01483953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006929044802858488,"score_gpt":0.2584579215598139,"score_spread":0.2515288767569554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}