{"id":"W2797097787","doi":"10.1177/2472555217750871","title":"Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Cancer Institute; Purdue University","keywords":"Computational biology; Peptidomimetic; DNA; Robustness (evolution); Biochemistry; Chemistry; Biology; Peptide; Combinatorial chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656065,0.0001086164,0.0002145116,0.0001102,0.0000240615,0.00001028957,0.00007404791,0.0001052304,7.184532e-7],"category_scores_gemma":[0.00007846006,0.00009479088,0.00005976497,0.0002399617,0.0001388172,0.000008835308,0.00007484473,0.00004417415,2.255634e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001185739,"about_ca_system_score_gemma":0.00003528709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003214744,"about_ca_topic_score_gemma":0.0001253585,"domain_scores_codex":[0.9992666,0.00002815355,0.0002232906,0.0002514258,0.00009218129,0.0001383625],"domain_scores_gemma":[0.9995833,0.00001082525,0.00009820495,0.0001770395,0.00009856407,0.00003206816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002787616,0.00005338945,0.001590928,0.00001772836,0.00002604747,2.903329e-7,0.00002097796,0.0000446003,0.9968588,0.00001004205,0.000170213,0.0009282213],"study_design_scores_gemma":[0.0002388309,0.000399258,0.001684885,0.00003494864,0.00002366579,0.000004479753,0.00005664308,0.0003736412,0.9969405,0.00003700375,0.00009356948,0.0001125549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880806,0.00005438742,0.01148441,0.00003647338,0.00003899439,0.00009558434,0.0000148783,0.000007687445,0.0001870429],"genre_scores_gemma":[0.9950148,0.00005013767,0.004526734,0.0000361374,0.0001029949,0.000003828066,0.00002014206,0.00001038832,0.0002348583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006957679,"threshold_uncertainty_score":0.386546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006929044802858488,"score_gpt":0.2584579215598139,"score_spread":0.2515288767569554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}