{"id":"W2797124689","doi":"10.1124/jpet.118.249292","title":"Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β2-Adrenoceptor Agonists","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Health Research Board; American Society for Pharmacology and Experimental Therapeutics","keywords":"Indacaterol; Formoterol; Transcriptome; Reporter gene; Salmeterol; Pharmacology; Proinflammatory cytokine; Gene expression; Biology; Chemistry; Gene; Inflammation; Immunology; Bronchodilator; Asthma; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008491697,0.0001579415,0.0003359903,0.0002613734,0.0003141913,0.0003995975,0.00008814468,0.0002360338,0.001787603],"category_scores_gemma":[0.0001371872,0.0001464416,0.0003830783,0.0003630324,0.0001546401,0.0001854999,0.0001623972,0.0005005107,0.0004780584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895919,"about_ca_system_score_gemma":0.0002682927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007961345,"about_ca_topic_score_gemma":0.001496823,"domain_scores_codex":[0.999833,0.00001843746,0.00000969863,0.00004483835,0.00005139978,0.0000427008],"domain_scores_gemma":[0.999938,0.00001449879,0.0000120839,0.000008197757,0.00001614863,0.0000111207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961305,0.00001535068,0.001084093,0.00002996318,0.000006062634,0.00003433351,0.00003162576,0.00003775749,0.9972854,0.00002737175,0.00005080312,0.001201085],"study_design_scores_gemma":[0.00003291642,0.000651832,0.3125661,0.00002620165,0.00008778567,0.000673702,0.0006177498,0.002261786,0.6775367,0.0001771124,0.005345866,0.00002222382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902101,0.001587207,0.001754089,0.0002101924,0.00005204437,0.00003981261,0.004392708,0.00004601313,0.001707792],"genre_scores_gemma":[0.9840938,0.001759569,0.002764805,0.000219887,0.0000390976,0.0001444992,0.006762932,0.00003299572,0.004182502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787603,"threshold_uncertainty_score":0.005980134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439600251920468,"score_gpt":0.3235461453202972,"score_spread":0.3091501428010925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}