{"id":"W2797184297","doi":"10.1128/mbio.00543-18","title":"A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Biofilm; Microbiology; Pseudomonas aeruginosa; Innate immune system; Elastase; Proteases; Serine protease; Extracellular matrix; Biology; Viral matrix protein; Immune system; Matrix (chemical analysis); Chemistry; Protease; Bacteria; Cell biology; Enzyme; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001829784,0.000300621,0.000249275,0.00004843332,0.0002070505,0.00009903899,0.0002024279,0.0003995095,0.0001132432],"category_scores_gemma":[0.0002142832,0.0002768378,0.0001307096,0.0001713124,0.0002027399,0.000009030275,0.0001863157,0.0001583181,0.0002688385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000389888,"about_ca_system_score_gemma":0.0001426647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002968799,"about_ca_topic_score_gemma":0.0001237399,"domain_scores_codex":[0.9982476,0.0001131278,0.000311245,0.0006312747,0.0001846938,0.0005121073],"domain_scores_gemma":[0.9989513,0.00000825366,0.0001804566,0.0005120593,0.0001740659,0.0001738415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002077461,0.0001130575,0.0007792925,0.00001362589,0.00006358138,0.00001147336,0.00005533662,2.728401e-7,0.9939201,0.000007364732,0.003801803,0.001026315],"study_design_scores_gemma":[0.001086634,0.000615972,0.002216894,0.00007660126,0.00002598447,0.00001026417,0.00002255574,0.00005191293,0.9745367,0.00002707088,0.02092796,0.0004014937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970667,0.0001228866,0.00004929848,0.0003821659,0.0004640415,0.001262527,0.000129242,0.00007736973,0.0004457296],"genre_scores_gemma":[0.994412,0.000007374655,0.00202697,0.000302536,0.001690932,0.00007789161,0.0002946683,0.00005159466,0.001136056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01938347,"threshold_uncertainty_score":0.9999684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333023786563881,"score_gpt":0.2531968940214029,"score_spread":0.2398666561557641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}