{"id":"W2797208961","doi":"10.1158/1541-7786.mcr-17-0784","title":"Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Quebec - Clinical Research Organization in Cancer","funders":"Fonds de Recherche du Québec - Santé; Government of Canada; Canadian Urological Association; Ferring; Canadian Institutes of Health Research; Canadian Urological Oncology Group","keywords":"Microvesicles; Cancer-Associated Fibroblasts; Stromal cell; Cancer research; Exosome; Cancer cell; Cell biology; Bladder cancer; SMAD; Cancer; Transforming growth factor; Metastasis; Tumor microenvironment; Fibroblast; Chemistry; Biology; microRNA; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913539,0.0002315866,0.0001345435,0.0001875276,0.0001175412,0.0003032268,0.000065092,0.0001753754,0.001439759],"category_scores_gemma":[0.0001064371,0.00009171351,0.0002828185,0.0001017137,0.0001149138,0.0001664505,0.0002484546,0.0003368368,0.0003820296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708404,"about_ca_system_score_gemma":0.000187578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000271471,"about_ca_topic_score_gemma":0.0003619444,"domain_scores_codex":[0.9998858,0.0000320332,0.00001182531,0.00001381125,0.00003183473,0.00002472454],"domain_scores_gemma":[0.999935,0.00001994225,0.00001342468,0.000009539202,0.00001016227,0.0000118539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333483,0.00004701145,0.0003953345,0.00005678429,0.000007186868,0.0001198447,0.00002662988,0.00004832046,0.9955819,0.0002366116,0.0001275739,0.003219333],"study_design_scores_gemma":[0.00004194487,0.0003068318,0.006156461,0.00001664517,0.00001809877,0.0004867703,0.0000546694,0.0008397556,0.984792,0.0001474207,0.007135635,0.000003822806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986941,0.003628499,0.004460182,0.0001989944,0.0000875152,0.00006786788,0.0004670091,0.00009257668,0.004056253],"genre_scores_gemma":[0.9924223,0.001792246,0.001988929,0.00006237033,0.00001485018,0.00004128545,0.0003082546,0.00001449301,0.003355285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001439759,"threshold_uncertainty_score":0.004816473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03944720025024814,"score_gpt":0.3791884721646274,"score_spread":0.3397412719143793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}