{"id":"W2797282777","doi":"10.1016/j.cell.2018.03.057","title":"Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":875,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stand Up To Cancer; National Institutes of Health; CRUK Lung Cancer Centre of Excellence; Cancer Research UK; Novo Nordisk Fonden; Breast Cancer Research Foundation; Rosetrees Trust; National Institute for Health and Care Research; Ministerio de Economía y Competitividad; Wellcome Trust; Francis Crick Institute; National Cancer Institute; University College London; Institute of Cancer Research; Medical Research Council; Celgene; Royal Marsden Cancer Charity","keywords":"Biology; Clear cell renal cell carcinoma; Metastasis; Phenotype; Renal cell carcinoma; Primary tumor; Cancer research; Tumor progression; Pathology; Cancer; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936796,0.0001195598,0.0002261148,0.0003344307,0.0001986524,0.0004500622,0.0001478634,0.0002680186,0.0007119472],"category_scores_gemma":[0.0002037331,0.0001341231,0.0001058327,0.0002588071,0.0002052547,0.0002109689,0.0001921242,0.0002723857,0.000112824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003722289,"about_ca_system_score_gemma":0.0002183222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004407336,"about_ca_topic_score_gemma":0.006447443,"domain_scores_codex":[0.9999239,0.00001327841,0.000002493681,0.00002308201,0.0000206292,0.00001654031],"domain_scores_gemma":[0.9999262,0.00002000367,0.00002213499,0.000009122077,0.00001071675,0.00001175486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002250182,0.0000193962,0.03480874,0.00004818525,0.00002092125,0.0001929575,0.0001355354,0.0007143054,0.9545897,0.0003804881,0.00006641706,0.008798332],"study_design_scores_gemma":[0.00002439484,0.0005760345,0.3794904,0.0000177464,0.0001042574,0.003799575,0.0004484799,0.01879717,0.5893244,0.0004347989,0.006958966,0.00002377366],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939114,0.00124117,0.003922206,0.00002607447,0.000001977445,0.00001123339,0.0001291097,0.00003167136,0.0007251634],"genre_scores_gemma":[0.9959304,0.000379516,0.002806673,0.000008546295,0.000001134967,0.000008921395,0.0001563803,0.000009254022,0.0006991997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004407336,"threshold_uncertainty_score":0.008763373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381055547696047,"score_gpt":0.2980480197035847,"score_spread":0.2642374642266242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}