{"id":"W2797311466","doi":"10.1038/s41598-018-24357-4","title":"Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Fondation pour la Recherche Médicale; University of Alberta; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Maculopathy; Ophthalmology; Macula Lutea; Medicine; Optometry; Retinal; Retinopathy; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490457,0.0003873685,0.0001957611,0.000443586,0.000223663,0.0002606771,0.0001635127,0.0005884164,0.002135218],"category_scores_gemma":[0.0001105478,0.0001933551,0.0004210817,0.0001681553,0.0004542477,0.0002841921,0.0003936743,0.0006945152,0.0004996736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003815726,"about_ca_system_score_gemma":0.0002627093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000823188,"about_ca_topic_score_gemma":0.001094895,"domain_scores_codex":[0.9998415,0.00002006713,0.00001637347,0.00004199302,0.00004945779,0.00003069745],"domain_scores_gemma":[0.9998275,0.00001352606,0.0000755381,0.00001514274,0.00001427277,0.00005390527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001340636,0.00002205403,0.0004484717,0.00004806352,0.000005866608,0.000777912,0.00003122796,0.0000237713,0.9973603,0.000105444,0.00005803375,0.0009847295],"study_design_scores_gemma":[0.0000445714,0.0006272094,0.04917853,0.00001882268,0.00003923963,0.01166164,0.0001330918,0.000546851,0.9322067,0.0003057489,0.005223411,0.00001413437],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917334,0.002568603,0.002610733,0.0001876625,0.00005750412,0.00004676662,0.000735491,0.0002117922,0.00184808],"genre_scores_gemma":[0.9919957,0.001121266,0.002048697,0.00008861629,0.00000828195,0.00004468495,0.000478837,0.00004401362,0.004169962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135218,"threshold_uncertainty_score":0.007143021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008127271630948748,"score_gpt":0.2380069481459557,"score_spread":0.2298796765150069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}