{"id":"W2797311466","doi":"10.1038/s41598-018-24357-4","title":"Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Fondation pour la Recherche Médicale; University of Alberta; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Maculopathy; Ophthalmology; Macula Lutea; Medicine; Optometry; Retinal; Retinopathy; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006203206,0.000169564,0.000131087,0.0001283455,0.0001834383,0.0001461717,0.0001297171,0.0001322311,0.0001519882],"category_scores_gemma":[0.0001145245,0.0001589453,0.00007594394,0.0003265275,0.0001654162,0.00001490605,0.00009460201,0.00007071302,0.00006220647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000286948,"about_ca_system_score_gemma":0.0002086552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002173448,"about_ca_topic_score_gemma":0.0002094769,"domain_scores_codex":[0.9981579,0.00004934298,0.0003640534,0.0007598953,0.0003216141,0.0003471993],"domain_scores_gemma":[0.9990811,0.000003828227,0.0001637575,0.0004910224,0.0001660252,0.00009425862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007636488,0.00005036983,0.02042939,0.000009231604,0.000009081636,0.00005418625,0.0001741114,0.000001371944,0.9613473,0.000006830244,0.01626288,0.001578909],"study_design_scores_gemma":[0.0003051704,0.0001494539,0.01804346,0.00001979063,0.000007403398,0.00007033437,0.0001193654,0.00003149148,0.8547952,0.0004489547,0.125707,0.000302402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877107,0.0001595272,0.00005225473,0.00003292056,0.005341187,0.0002875406,0.000001253587,0.00002302337,0.006391626],"genre_scores_gemma":[0.9957643,0.00000913815,0.0003617042,0.00008419604,0.0001785494,0.00002557202,0.0003062273,0.00001811583,0.003252222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094442,"threshold_uncertainty_score":0.64816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008127271630948748,"score_gpt":0.2380069481459557,"score_spread":0.2298796765150069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}