{"id":"W2797339573","doi":"10.3390/vaccines6020023","title":"“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy","year":2018,"lang":"en","type":"review","venue":"Vaccines","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Host (biology); Vaccination; Identification (biology); Virology; Virus; Biology; Vaccine efficacy; Immunology; Influenza vaccine; Host response; Immune system; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005482074,0.0005808317,0.0008950534,0.002158807,0.0002720143,0.0009251257,0.0006641023,0.001120646,0.003507959],"category_scores_gemma":[0.0007774971,0.0001807495,0.0006152546,0.00123332,0.0004237937,0.001221124,0.0005632828,0.001490364,0.001382283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005086726,"about_ca_system_score_gemma":0.0009932006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009335543,"about_ca_topic_score_gemma":0.001813475,"domain_scores_codex":[0.9998092,0.00004618106,0.00003119163,0.00002791566,0.00006415477,0.00002131414],"domain_scores_gemma":[0.9997725,0.0001196888,0.00003190701,0.000006792385,0.00005074462,0.00001836228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007863845,0.00007797068,0.0002673762,0.03769279,0.0001576853,0.0002126213,0.0001143632,0.0002656507,0.00250241,0.005057268,0.02856618,0.9250071],"study_design_scores_gemma":[0.00001658272,0.0001051833,0.0009223684,0.006566988,0.0001360916,0.001277289,0.00008309219,0.00006883391,0.0007083802,0.002061437,0.9880383,0.00001564321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001405117,0.9984574,0.00008122488,0.00038157,0.000196476,0.00000468917,0.0000129546,0.000006310787,0.0007188176],"genre_scores_gemma":[0.0008663085,0.9981685,0.0001523359,0.0002488494,0.0001100048,0.000005486832,0.00001965896,0.000001167558,0.0004277247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003507959,"threshold_uncertainty_score":0.01173532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330090379500457,"score_gpt":0.4383204254434088,"score_spread":0.3053113874933632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}