{"id":"W2797350306","doi":"10.1016/j.cellsig.2018.02.015","title":"Extracellular nucleotides enhance agonist potency at the parathyroid hormone 1 receptor","year":2018,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Parathyroid hormone; Receptor; Agonist; Extracellular; Signal transduction; Chemistry; Allosteric regulation; Cell biology; Endocrinology; Internal medicine; Biology; Biochemistry; Calcium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000442686,0.0002940897,0.000194727,0.00003224036,0.0006803493,0.00007815835,0.0004649803,0.0001915057,0.0004488699],"category_scores_gemma":[0.00006152839,0.0002329638,0.0001789555,0.0001582123,0.0003316154,0.000008454324,0.0002145458,0.0001799612,0.0005312328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002635369,"about_ca_system_score_gemma":0.00006110478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002696895,"about_ca_topic_score_gemma":0.00000658973,"domain_scores_codex":[0.9981871,0.0001129381,0.0003645368,0.000593594,0.0002504906,0.0004913648],"domain_scores_gemma":[0.9989494,0.00003434898,0.0001592686,0.0005705192,0.0001585213,0.0001279161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009509432,0.00003852011,0.00004970338,0.000006901872,0.00005359361,0.00001270577,0.0001255435,0.0001421922,0.9700541,0.0001084919,0.02888956,0.0004235312],"study_design_scores_gemma":[0.0002004023,0.0002481923,0.00001750802,0.00001395801,0.00002979643,0.00001206592,0.00008237216,0.0002225828,0.7889674,0.00006731728,0.2098578,0.0002806368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876976,0.07646219,0.03329862,0.000257654,0.0002179687,0.0002191074,0.00001021772,0.0000376952,0.001798947],"genre_scores_gemma":[0.9747645,0.0006523698,0.001116743,0.0002135493,0.002182054,0.00002271784,0.0001543702,0.0000621275,0.02083161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1810868,"threshold_uncertainty_score":0.949999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009987323953894464,"score_gpt":0.2319090271551169,"score_spread":0.2219217032012225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}