{"id":"W2797361465","doi":"10.1371/journal.pone.0191172","title":"Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiovascular Health and Disease Prevention","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Ministry of Cultural Affairs; Provincia autonoma di Bolzano - Alto Adige; Wirtschaftsagentur Wien; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Stockholms Läns Landsting; ZonMw; Bundesministerium für Verkehr, Innovation und Technologie; Hjärt-Lungfonden; Academy of Finland; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; National Institute on Aging; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Standortagentur Tirol; National Institute of Dental and Craniofacial Research; Universität Greifswald; Amgen; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Sanofi; European Commission; Vetenskapsrådet; Ministero della Salute; Pfizer; National Institute of Neurological Disorders and Stroke; British Heart Foundation","keywords":"Intima-media thickness; Medicine; Internal medicine; Cardiology; Hazard ratio; Myocardial infarction; Confidence interval; Proportional hazards model; Surrogate endpoint; Stroke (engine); Carotid arteries","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00988321,0.0005905961,0.001149903,0.001427401,0.0002738326,0.001152765,0.0009094137,0.001003489,0.0008482517],"category_scores_gemma":[0.01451842,0.0004434986,0.002249645,0.001592245,0.0003972004,0.0005910207,0.001303139,0.0009450858,0.0002913239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002429369,"about_ca_system_score_gemma":0.0003608684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002257264,"about_ca_topic_score_gemma":0.001815081,"domain_scores_codex":[0.9953077,0.001891452,0.0004656652,0.001377125,0.0008027969,0.0001552276],"domain_scores_gemma":[0.9847414,0.005293781,0.00543356,0.002439213,0.001411618,0.0006804454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002116687,0.00002290864,0.9862293,0.0001627452,0.003881871,0.00004566698,0.00007047414,0.0004193669,0.0001852804,0.00005956688,0.0004645208,0.006341691],"study_design_scores_gemma":[0.0001381527,0.0003684309,0.9949122,0.00006493444,0.002083596,0.0003666862,0.00005100074,0.0005470135,0.000178798,0.0002341992,0.001028892,0.00002612887],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608657,0.02320846,0.002189402,0.0004331813,0.0001381905,0.00007692923,0.01014791,0.00007411537,0.002866282],"genre_scores_gemma":[0.9904178,0.002020993,0.0009266849,0.0001085935,0.0001528263,0.00006707312,0.005905904,0.0000259428,0.0003743196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00988321,"threshold_uncertainty_score":0.05226803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05199314660385913,"score_gpt":0.2755705807108333,"score_spread":0.2235774341069742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}