{"id":"W2797361465","doi":"10.1371/journal.pone.0191172","title":"Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiovascular Health and Disease Prevention","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Ministry of Cultural Affairs; Provincia autonoma di Bolzano - Alto Adige; Wirtschaftsagentur Wien; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Stockholms Läns Landsting; ZonMw; Bundesministerium für Verkehr, Innovation und Technologie; Hjärt-Lungfonden; Academy of Finland; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; National Institute on Aging; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Standortagentur Tirol; National Institute of Dental and Craniofacial Research; Universität Greifswald; Amgen; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Sanofi; European Commission; Vetenskapsrådet; Ministero della Salute; Pfizer; National Institute of Neurological Disorders and Stroke; British Heart Foundation","keywords":"Intima-media thickness; Medicine; Internal medicine; Cardiology; Hazard ratio; Myocardial infarction; Confidence interval; Proportional hazards model; Surrogate endpoint; Stroke (engine); Carotid arteries","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003510898,0.0002235972,0.001236818,0.0001432328,0.0001270541,0.000008773834,0.0001344353,0.000214018,0.000005339597],"category_scores_gemma":[0.001907055,0.0001832239,0.000694255,0.0004766741,0.0001366639,0.0001617069,0.000139853,0.0001853691,0.00000355811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375861,"about_ca_system_score_gemma":0.0001834951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002614593,"about_ca_topic_score_gemma":0.0003334851,"domain_scores_codex":[0.9964589,0.001021696,0.000702258,0.0005155045,0.001007355,0.0002942181],"domain_scores_gemma":[0.9972769,0.0004437916,0.0003405442,0.0008967371,0.0008681404,0.0001738869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02120361,0.007108187,0.7835923,0.009421361,0.1101601,0.00003133143,0.04721469,0.0006382028,0.008258884,0.0004337328,0.0003221646,0.01161544],"study_design_scores_gemma":[0.01527284,0.0004701181,0.9374463,0.001697709,0.01250721,0.000003267473,0.000336887,0.001137879,0.03020453,0.0005874544,0.0001203379,0.0002154879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723462,0.0182106,0.0001306138,0.0002498425,0.0001423172,0.005677063,0.003188812,0.00002785091,0.00002673327],"genre_scores_gemma":[0.9947569,0.002282938,0.0006654022,0.00006581105,0.0005870361,0.0007126263,0.0008875953,0.00003589463,0.000005740631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.153854,"threshold_uncertainty_score":0.7471654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05199314660385913,"score_gpt":0.2755705807108333,"score_spread":0.2235774341069742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}