{"id":"W2797375388","doi":"10.1016/j.jmb.2018.04.008","title":"Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm","year":2018,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Children's Cancer Foundation","keywords":"Intrinsically disordered proteins; Transcription factor; Paradigm shift; Computational biology; Biology; Biophysics; Genetics; Physics; Gene; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438313,0.0008408549,0.001421967,0.001072681,0.0003389218,0.001597238,0.001457163,0.001958502,0.001985471],"category_scores_gemma":[0.001190197,0.0003714526,0.000400671,0.001062421,0.001472193,0.002875056,0.001186855,0.003673251,0.00136391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009580649,"about_ca_system_score_gemma":0.0008829983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004351176,"about_ca_topic_score_gemma":0.0009657347,"domain_scores_codex":[0.9997333,0.00004621949,0.00003422564,0.00005061185,0.00009317577,0.0000425178],"domain_scores_gemma":[0.9993678,0.0003451241,0.00006905445,0.00003012338,0.0001244931,0.00006342143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001741746,0.00007148526,0.0001843915,0.01002078,0.00007600987,0.0003677082,0.000118641,0.0008738689,0.01004104,0.02676677,0.04858882,0.9027163],"study_design_scores_gemma":[0.00001873535,0.00006618924,0.0001554733,0.0008529231,0.00004761971,0.0007709645,0.00003821584,0.0001658397,0.002232948,0.005725023,0.989907,0.00001889742],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001918272,0.9966885,0.0007568848,0.0009170766,0.000573163,0.000003820449,0.00001219831,0.00001734517,0.0008390981],"genre_scores_gemma":[0.002105878,0.9944306,0.0006943438,0.001150221,0.0006581543,0.00001188893,0.00003069159,0.000006067765,0.0009121774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001985471,"threshold_uncertainty_score":0.007606626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702537410603282,"score_gpt":0.3220244031912228,"score_spread":0.2949990290851899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}