{"id":"W2797437320","doi":"10.1016/j.cjca.2018.04.010","title":"Immune Checkpoint Inhibitors: Game Changing Cancer Therapy With a Cardiac Cost. What Are the Mechanisms and Unresolved Questions in Cardiotoxicity?","year":2018,"lang":"en","type":"letter","venue":"Canadian Journal of Cardiology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Immune system; Cancer; Immune checkpoint; Immunotherapy; Cancer immunotherapy; Cardiotoxicity; Clinical trial; Antigen; Scopus; Immunology; Cancer research; Internal medicine; Chemotherapy; MEDLINE; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003107868,0.0007037072,0.001920284,0.0005558482,0.002074411,0.003411947,0.001381896,0.0268494,0.007442297],"category_scores_gemma":[0.02199262,0.0002968592,0.001336362,0.0004366546,0.003970442,0.006926781,0.00141211,0.03486503,0.005317819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00306813,"about_ca_system_score_gemma":0.002343823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418668,"about_ca_topic_score_gemma":0.002684981,"domain_scores_codex":[0.9974588,0.0008570349,0.0003000756,0.0003138536,0.000799544,0.0002707389],"domain_scores_gemma":[0.9885291,0.007526445,0.0005817109,0.0002996314,0.001704489,0.00135865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001878831,0.0001241054,0.001086427,0.0002457122,0.00004601337,0.003930734,0.0001051003,0.0002820209,0.0004956563,0.01271671,0.8997108,0.08106885],"study_design_scores_gemma":[0.000434578,0.0003286297,0.0009973659,0.0009209004,0.00007175787,0.01046466,0.0005085904,0.0009723299,0.0004300232,0.06774443,0.9170274,0.00009939931],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002670022,0.009791939,0.0001291341,0.9811219,0.007420816,0.000004811395,0.0000225842,0.0000183819,0.001223438],"genre_scores_gemma":[0.008237947,0.01826087,0.0004577058,0.8564338,0.1130753,0.00002349707,0.0000403221,0.00002243394,0.003448149],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0268494,"threshold_uncertainty_score":0.02489698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762470368360843,"score_gpt":0.250300469472889,"score_spread":0.2326757657892806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}