{"id":"W2797510526","doi":"10.1101/298729","title":"STF-62247 blocks late stages of autophagy by disrupting lysosomal physiology","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"","keywords":"Autophagy; Endocytic cycle; ATG5; Cell biology; BECN1; Lysosome; Cathepsin D; Biology; Phenotype; Endosome; Autophagosome; Chemistry; Cell; Endocytosis; Gene; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032236,0.0002982446,0.0002597713,0.0002853253,0.0001048408,0.0002363178,0.0001780571,0.0002836339,0.001813923],"category_scores_gemma":[0.00007574409,0.00007835767,0.0002161894,0.0001306923,0.0001804413,0.0001349639,0.0001296952,0.0003619939,0.0005366041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175431,"about_ca_system_score_gemma":0.0002281705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004470136,"about_ca_topic_score_gemma":0.000407295,"domain_scores_codex":[0.9999315,0.00001214362,0.00000763485,0.000009476837,0.00001961705,0.00001959813],"domain_scores_gemma":[0.9999591,0.000009527403,0.00000678006,0.000004534975,0.000005919548,0.00001409541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002883379,0.00006810757,0.00009892605,0.00003429648,0.000005953608,0.0000690525,0.000007125882,0.00008311799,0.9971499,0.0001213417,0.00007033805,0.002003454],"study_design_scores_gemma":[0.00002779114,0.0003900867,0.0007463024,0.000002559697,0.000005511746,0.00007887802,0.000005414312,0.0002782731,0.9968086,0.0000323628,0.001622277,0.000001942655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927446,0.002317385,0.001606904,0.0001536571,0.00004907762,0.00003417552,0.0004255376,0.00008956611,0.002579129],"genre_scores_gemma":[0.9918504,0.00143204,0.001770836,0.00005707636,0.00002151808,0.00002994941,0.000566185,0.00002739985,0.004244578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813923,"threshold_uncertainty_score":0.00606817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146461575892443,"score_gpt":0.2516569324849405,"score_spread":0.2401923167260161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}