{"id":"W2797526531","doi":"10.21767/2576-1412.100018","title":"Characterization of an Alcohol Dehydrogenase of the Hyperthermophilic Archaeon Hyperthermus Butylicus","year":2018,"lang":"en","type":"article","venue":"Journal of Applied Microbiology and Biochemistry","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Butyraldehyde; Alcohol dehydrogenase; Acetaldehyde; Chemistry; Butanol; Enzyme; Alcohol oxidoreductase; Biochemistry; Alcohol; Acetone; Formate dehydrogenase; Enzyme kinetics; Ethanol; Dehydrogenase; Escherichia coli; Aldehyde dehydrogenase; Stereochemistry; Gene; NAD+ kinase; Cofactor; Catalysis; Active site","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001980496,0.0001185975,0.0002003525,0.00003149341,0.00004084416,0.000002713153,0.0001895176,0.000199072,0.000006384794],"category_scores_gemma":[0.00002452907,0.00007982745,0.00007527089,0.00007862155,0.000376226,0.000003124691,0.00006082009,0.00009836742,3.132772e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004832432,"about_ca_system_score_gemma":0.00005233025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001732814,"about_ca_topic_score_gemma":0.000001295247,"domain_scores_codex":[0.9993413,0.0000231932,0.0003228011,0.0001609204,0.00003730563,0.0001144879],"domain_scores_gemma":[0.9992157,0.000002683047,0.0003640462,0.0002291016,0.0001486361,0.00003978422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806061,0.00006956956,0.00008584587,0.00003779033,0.00006359756,3.144882e-7,0.00006146788,0.000002663178,0.9973392,0.000007625854,0.0000132597,0.002038051],"study_design_scores_gemma":[0.0004195473,0.0002021747,0.0005494115,0.00002232283,0.00003750805,0.0003354612,0.00002878451,0.00000197661,0.9965447,0.00001229891,0.001760695,0.00008513492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993329,0.000260179,0.00004001729,0.00005409729,0.0001559607,0.00007185533,0.00003515611,0.000002244532,0.00004761264],"genre_scores_gemma":[0.998969,0.0001160459,0.0002614049,0.00006560219,0.0005023343,0.000001077492,0.00003553573,0.00001006483,0.00003893007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952916,"threshold_uncertainty_score":0.3255269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003996656464521699,"score_gpt":0.1924689749560652,"score_spread":0.1884723184915435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}