{"id":"W2797535195","doi":"10.3389/fvets.2018.00057","title":"Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1","year":2018,"lang":"en","type":"article","venue":"Frontiers in Veterinary Science","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canterbury Medical Research Foundation; University of Calgary","keywords":"Efferocytosis; Leukotriene B4; Inflammation; Apoptosis; Proinflammatory cytokine; Tumor necrosis factor alpha; Chemokine; Lipid signaling; Immunology; Necrosis; Chemistry; Respiratory burst; Phospholipase A2; Biology; Macrophage; Pharmacology; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001647711,0.0002514927,0.0005016974,0.0006276466,0.0003980265,0.00003585515,0.0002669798,0.000189944,0.000002962245],"category_scores_gemma":[0.0004356997,0.0002016448,0.00002650939,0.0005761681,0.003657938,0.0006732048,0.0004084027,0.0002522857,4.29584e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002980766,"about_ca_system_score_gemma":0.0001609738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004926806,"about_ca_topic_score_gemma":0.000003389266,"domain_scores_codex":[0.997927,0.0003062236,0.00068491,0.0005747736,0.0001393938,0.0003677135],"domain_scores_gemma":[0.9987051,0.00009719854,0.0005122289,0.0003986741,0.000243966,0.00004283028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000470269,0.00005539618,0.03533669,0.0004629313,0.00003559427,0.000001880662,0.00324385,0.000003800574,0.9531082,0.00006753779,0.00004710045,0.007166748],"study_design_scores_gemma":[0.0005738501,0.00108467,0.2312897,0.0007275989,0.00002994762,0.0001050842,0.000697742,0.00005935468,0.7651749,0.00003262113,0.00006675976,0.0001578616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869643,0.01164274,0.00001190742,0.0001745365,0.000378466,0.0007761428,0.00001063146,0.00001811382,0.00002314438],"genre_scores_gemma":[0.9974478,0.00145,0.000999642,0.00001049185,0.00003698855,0.000005243844,0.000004364279,0.00001629722,0.0000291321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.195953,"threshold_uncertainty_score":0.9990535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148708118572615,"score_gpt":0.230915176527678,"score_spread":0.2160443646704165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}