{"id":"W2797535195","doi":"10.3389/fvets.2018.00057","title":"Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1","year":2018,"lang":"en","type":"article","venue":"Frontiers in Veterinary Science","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canterbury Medical Research Foundation; University of Calgary","keywords":"Efferocytosis; Leukotriene B4; Inflammation; Apoptosis; Proinflammatory cytokine; Tumor necrosis factor alpha; Chemokine; Lipid signaling; Immunology; Necrosis; Chemistry; Respiratory burst; Phospholipase A2; Biology; Macrophage; Pharmacology; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177542,0.0002266614,0.0001973069,0.000129837,0.00007073377,0.0002231677,0.00009906248,0.0002563765,0.0006206515],"category_scores_gemma":[0.0001167144,0.00006607552,0.0001961916,0.00008551505,0.000148668,0.0001759958,0.0001285962,0.0003096313,0.0001306373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147248,"about_ca_system_score_gemma":0.0001434395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003080331,"about_ca_topic_score_gemma":0.0005457243,"domain_scores_codex":[0.9998934,0.00002588841,0.00001470804,0.00001953089,0.00002203656,0.00002446447],"domain_scores_gemma":[0.999911,0.00001419433,0.00003872561,0.000008316169,0.00001237167,0.0000153444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001831795,0.00002583722,0.0002316116,0.00004066975,0.000003239,0.00002840904,0.000007672011,0.00001657338,0.9984671,0.000007434068,0.000005716959,0.0009825742],"study_design_scores_gemma":[0.00001955194,0.002055837,0.009138881,0.00001276884,0.00001659474,0.000232642,0.00004031038,0.0001949875,0.9871043,0.00001318294,0.001168246,0.000002638682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958879,0.002628715,0.0007946583,0.00005718608,0.00001531549,0.00001652005,0.00008400751,0.00001664692,0.0004990482],"genre_scores_gemma":[0.9966273,0.001478205,0.0008304821,0.00004407407,0.00001047031,0.00001363509,0.0001295015,0.000003626349,0.0008627277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006206515,"threshold_uncertainty_score":0.002076328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148708118572615,"score_gpt":0.230915176527678,"score_spread":0.2160443646704165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}